YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antitumor and Immunomodulatory Activities of the P. grandiflorum Cultivated for More Than 20 Years

다년생 도라지의 항암 및 면역활성

  • Published : 1998.08.01
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Abstract

Platycodon radix is a dried root of Platycodon grandiflorum (P. grandiflorum) A. DC, a perennial grown on the hills and fields in Korea and Japan, or cultivated in various districts. Recently, P. grandiflorum (Changkil) has been successfully cultivated for more than 20 years and generally has been employed as folk remedy for adult diseases such as hyperlipidemia, hypertension and diabetes. We investigated various biological activities of the extracts from Changkil. When treated in vitro with B16-F1 mouse melanoma cell lines, it showed 100% laminin-binding inhibitory activities at the concentration over 0.125mg/ml. In in vivo test it showed 61.5% reduction of the solid tumor weight transplanted in mice and exhibited anticancer activity of 128% ILS against Sarcoma-180 ascites. It also increased the ratio of positive cells of natural killer cells in lymphocytic composition against Sarcoma-18O ascites and solid tumor transplanted in ICR mice when tests were carried out by FACScan method.

Keywords

References

  1. 동의보감 허준
  2. 생약학 한대석
  3. Kor. J. Pharmacog. v.5 Statistical analyses of Platycodi radix prescriptions Hong, M. W.
  4. Chem. Pharm. Bull. v.20 Chemical studies of oriental plant drugs Akiyama, T.;Tanaka, O.;Shibata, S.
  5. Chem. Pharm. Bull. v.23 Saponins of the root of P. grandiflorum. Isolation and the structure of platycodin D Tada, T.;Kaneiwa, Y.;Shoji, J.;Shibat, S.
  6. J. Chem. Soc., Perkin trans Ⅰ Saponins from roots of Platycodon grandiflorum Ishii, H.;Tori, K.;Tozyo, T.;Yoshimura, Y.
  7. Sogoigaku v.3 Igarashi, K.
  8. J. Pharm. Soc. Kor. v.19 Pharmacological activities of crude paltycodon Lee, E. B.
  9. Mycopathologia v.66 Hitokoto, H.;Morozumi, S.;Wake, T.;Sakai, S.;Ueno, I.
  10. Shoyakugaku Zasshi v.40 Immune pharmacological studies on platycodi radix Ⅰ: Effect on the phagocytosis in the mouse Nagao, T.;Matsuda, H.;Nambo, K.;Kubo, M.
  11. Shoyakugaku Zasshi v.40 Immune pharmacological studies on platycodi radix Ⅰ: Antitumor activity of inulin from Platycodi radix Naga, T.;Matsuda, H.;Makata, K.;Namba;Kubo, M.
  12. JP60-89427 Antitumor inulin-like substances from Platycodon grandiflorum roots, Kubo, M.
  13. JP平3-264534 マルコ-ル吸收制御劑 加藤珠子;關口珠子;川口誠
  14. 대한민국 특허 제045731호 다년생도라지재배법 이성호
  15. J. Korean Soc. Food Sci. Nutr. v.25 Effect of Platycodon grandiflorum extracts on blood glucose and lipid composition in Alloxan induced hyperglycermic rats Sung, N. K.;Lee, S. J.;Shin, J. H.;Kee, I. S.;Chung, Y. C.
  16. J. Nutr. Sci. Vitaminol. v.41 Effects of Platycodon grandiflorum feeding on serum and liver lipid concentations in rats with diet-induced hyperlipidemia Kim, K. S.;Ezaki, O.;Ikemoto, S.;Itakura, H.
  17. Proceeding of the American Association for Cancer Research v.30 Correlation of screening data generated with a tetrazolium assay (MTT) versus a protein assay (SRB) against a broad panel of human tumor cell lines Rubinstein, L. V.;Paull, K. D.;Shoemaker, R. H.;Simon, R. M.;Skehan, P.;Boyd, M. R.
  18. J. Natl. Cancer Inst. v.82 no.13 New colorimetric cytotoxicity assay for anticancer-drug screening Skehan, P.;Storeng, R.;Scudiero, D.;Monk, A.;McMahon, J. D.;Vista, J.;Warren, T.;Kenney, S.;Boyd, M. R.
  19. Proceedings of the American Assodiation for Cancer Research v.30 Evaluation of colorimetric protein and biomass strains for assaying in vitro drug effects upon human tumor cell lines Skehan, P.;Storeng, R.;Scuderio, N.;Boyd, M.