Archives of Pharmacal Research
- Volume 21 Issue 6
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- Pages.749-752
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and In Vitro Cytotoxicity of 3- or 4-Dialkylaminomethyl-1-azaanthraquinones
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Lee, Hee-Soon
(College of Pharmacy, Chungbuk National University)
;
- Choi, Jae-Young (College of Pharmacy, Chungbuk National University) ;
- Lee, Seung-Il (College of Pharmacy, Chungbuk National University) ;
- Hong, Seoung-Soo (College of Pharmacy, Chungbuk National University) ;
- Cho, Jung-Sook (College of Medicine, Dongguk University) ;
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Kim, Young-Ho
(College of Pharmacy, Chungnam National University)
- Published : 1998.12.01
Abstract
Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human can cer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.