Topoisomerase I Inhibitors from the Streptomyces sp. Strain KM86-9B Isolated from a Marine Sponge

  • Lee, Hong-Kum (Microbiology Lab., Korea Ocean Research & Development Institute) ;
  • Lee, Deuk-Soo (Microbiology Lab., Korea Ocean Research & Development Institute) ;
  • Lim, Jung-Hyun (Microbiology Lab., Korea Ocean Research & Development Institute, Department of Horticulure Science, Kon-Kuk University) ;
  • Kim, Jung-Sun (College of Pharmacy, Pusan National University) ;
  • Im, Kwang-Sik (College of Pharmacy, Pusan National University) ;
  • Jung, Jee H. (College of Pharmacy, Pusan National University)
  • 발행 : 1998.12.01

초록

The crude extract of Streptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the ca usative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.

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