Archives of Pharmacal Research
- 제21권6호
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- Pages.698-702
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Pharmacokinetics of Propentofylline and the Quantitation of Its Metaolite Hydroxypropentofylline in Human Volunteers
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Kwon, Oh-Seung
(Toxicology Lab., Bioanalysis and Biotransformation Researh Center, Korea Institute of Science and Technology) ;
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Chung, Youn-Bok
(College of Pharmacy, Chungbuk National University) ;
- Kim, Min-Hee (Toxicology Lab., Bioanalysis and Biotransformation Researh Center, Korea Institute of Science and Technology) ;
- Hahn, Hoh-Gyu (Medicinal Chemistry Research Center, Division of Applied Sciences, Kore Institute of Science and Tehnology) ;
- Rhee, Hee-Kyung (Medicinal Chemistry Research Center, Division of Applied Sciences, Kore Institute of Science and Tehnology) ;
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Ryu, Jae-Chun
(Toxicology Lab., Bioanalysis and Biotransformation Researh Center, Korea Institute of Science and Technology)
- 발행 : 1998.12.01
초록
Propentofylline (PPF, 3-methyl-1-(5-oxohexyl)-7-propylxanthine) has been reported to be effective for the treatment of both vascular dementia and dementia of the Alzheimer type. The pharmacological effects of PPF may be exerted via the stimulation of nerve growth factor, increased cerebral blood flow, and inhibition of adenosine uptake. The objectives of this experiment are to determine the kinetic behavior of PPF, to identify, and to quantify its metabolite in human. Blood samples were obtained from human volunteers following oral administration of 200mg of PPF tablets. For the identification and quantification of the metabolite, 3-methyl-1-(5-hydroxyhexyl)-7-propylxanthine (PPFOH), PPFOH was synthesized and identified by gas chromatography/mass spectroscopy (GC/MS) and