Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)

Korean Environmental Mutagen Society (한국환경성돌연변이발암원학회)
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Development of Anticancer Agents from Korean Medicinal Plants. Part 7. Cytotoxic Activity of the Chloroform soluble Fraction of Perrila frutescens Against Human Oral Epitheloid Carcinoma Cells

한국산 생약으로 부터 항암물질의 개발 (제7보), 소엽의 Chloroform 가용성 분획이 인체 구강유상피암종세포에 미치는 세포독성작용

  • Han, Du-Seok (Department of Oral Anatomy, school of Dentistry, Wonkwang University) ;
  • Kim, Young-Il (Department of Oral Anatomy, school of Dentistry, Wonkwang University) ;
  • Choi, Kyw-Eun (Department of Chemistry, College of Natural Sciences, Wonkwang University) ;
  • Kwag, Jung-Suk (Department of Dental hygenic, Mokpo Junior College) ;
  • Baek, Seung-Hwa (Department of Chemistry, College of Natural Sciences, Wonkwang University)
  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 김영일 (원광대학교 치과대학 구강해부학교실) ;
  • 최규은 (원광대학교 자연과학대학 화학과) ;
  • 곽정숙 (목포전문대학 치위생과) ;
  • 백승화 (원광대학교 자연과학대학 화학과)
  • Published : 1998.03.01
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Abstract

In the present study, we have evaluated cytotoxic effects of the chloroform soluble fraction of the methanolic extract of Perilla frutescens in human oral epitheloid carcinoma cells. The light microscopic study showed morphological changes of the treated cells. Cell membrane damaging activity was measured by the lactate dehydrogenase (LDH) assay and disruptions in cell organelles were determined by 3-(4,5-dime-thylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), neutral red (NR) and sulforhodamine protein B (SRB) of colorimetric assay. These results suggest that Perilla frutescens retains a potential antitumor activity.

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