한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)
- 제18권1호
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- Pages.32-36
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- 1998
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- 1225-6307(pISSN)
생강성분 6-Paradol의 세포 독성 및 병리학적 연구
Cytotoxicological and Pathological Studies of 6-Paradol, a Pungent Principle of Ginger
- Kim, Ok-Hee (Korea Food and Drug Administration, Toxicological Res., Dept. of Pathology) ;
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Yoo, Eun-Sook
(Dae Woong Pharm. Co. Central Research) ;
- Jung, In-Kyung (Sahm Yook University, Dept. of Pharmacy) ;
- Lee, Sang-Sup (Seoul National University, College of Pharmacy)
- 발행 : 1998.03.01
초록
It is previously reported that 6-paradol can induce prolonged analgesia in experimental animals. In order to investigate the mutagenicity of 6-paradol, Ames Samonella/microsome plate assay was carried out with Salmonella typhimurium strains, TA 98, TA 100, TA 1535 and TA 1538, 6-Paradol was nonmutagenic in Salmonella typhimurium with and without rat liver microsomal activation. The rec assay with Bacillus substilis strains H 17