Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)

Korean Environmental Mutagen Society (한국환경성돌연변이발암원학회)
권호 표지

Cytotoxicological and Pathological Studies of 6-Paradol, a Pungent Principle of Ginger

생강성분 6-Paradol의 세포 독성 및 병리학적 연구

  • Kim, Ok-Hee (Korea Food and Drug Administration, Toxicological Res., Dept. of Pathology) ;
  • Yoo, Eun-Sook (Dae Woong Pharm. Co. Central Research) ;
  • Jung, In-Kyung (Sahm Yook University, Dept. of Pharmacy) ;
  • Lee, Sang-Sup (Seoul National University, College of Pharmacy)
  • 김옥희 (식품의약품안전본부 독성연구소 병리부) ;
  • 유은숙 (대웅제약 중앙연구소) ;
  • 정인경 (삼육대학교 약학부) ;
  • 이상섭 (서울대학교 약학대학)
  • Published : 1998.03.01
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Abstract

It is previously reported that 6-paradol can induce prolonged analgesia in experimental animals. In order to investigate the mutagenicity of 6-paradol, Ames Samonella/microsome plate assay was carried out with Salmonella typhimurium strains, TA 98, TA 100, TA 1535 and TA 1538, 6-Paradol was nonmutagenic in Salmonella typhimurium with and without rat liver microsomal activation. The rec assay with Bacillus substilis strains H 17 $rec^+$ and M 45 $rec^+$ was carried out ot test 6-paradol and other compounds (1-3 mg/disc) for DNA damaging activity, 6-Paradol was also nonmutagenic in DNA damaging activity. The relative size of the inhibition zone for 6-paradol was smaller than that of capsaicin. We have also determined the pathological effects of this compound on the various tissues of rats after administrating(i.p.) with increasing doses of 4, 8, 12, 16 mg/kg at 2 hour intervals and found no significant changes in terms of histology.

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