Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Mutagenecity Test of Intralipidos

Intralipidos에 대한 변이원성시험

  • Jung, Ji-Youn (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Won-Woo (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Ihm, Jong-Hee (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Nam, Jeong-Seok (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Che, Jeong-Hwan (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Li, Guang-Xun (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Byeong-Cheol (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Yi, Beoung-Hi (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Park, Jae-Hak (Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Yong-Soon (Department of Public Health, College of Veterinary Medicine, Seoul National University)
  • 정지윤 (서울대학교 수의과대학 공중보건학교실) ;
  • 이원우 (서울대학교 수의과대학 공중보건학교실) ;
  • 임종희 (서울대학교 수의과대학 공중보건학교실) ;
  • 남정석 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 이광훈 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 이병희 (서울대학교 수의과대학 공중보건학교실) ;
  • 박재학 (서울대학교 수의과대학 실험동물의학교실) ;
  • 이영순 (서울대학교 수의과대학 공중보건학교실)
  • Published : 1998.09.01
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Abstract

In order to evaluate the mutagenic potential of Intralipidos produced by Greenmate cooperation. We performed Salmonella typhimurium reversion assay, chromosomal aberration test on chinese hamster ovarian cells and in vivo micronucleus assay using mouse bone marrow cells. In the reverse mutation test using Salmonella typhimurium TA98 and TA100, Intralipidos did not increase the number of revertant at any of the concentration tested in this study. Intralipidos did not increase the number of cells having structural or numberical chromosome aberration in cytogenetic test. In mouse micronucleus test, no significant increase were observed in the occurrence of micornucleated polychromatic erythrocytes in ICR male mice intraperitoneally administered with Intralipidos. These results indicate that Intralipidos has no genetic toxicity under these experimental conditions.

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