Toxicological Research
- Volume 14 Issue 3
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- Pages.427-433
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Acute and Genetic Toxicity Study of DK1002, a Drug Candidate for Analgesics
DK1002에 대한 급성독성시험 및 유전독성에 관한 연구
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Kim, Kyung-Ran (Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Kim, Hyun-Joo (Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Jung, Sang-Oun (Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Kim, Myung-Kuk (Dong-Kook Pharmaceutical Co. Ltd.) ;
- Park, Hee-Sock (Dong-Kook Pharmaceutical Co. Ltd.) ;
- Kim, Yong-Hae (Korea Advanced Institute of Science and Technology)
- 류재천 (한국과학기술연구원, 독성연구팀) ;
- 김경란 (한국과학기술연구원, 독성연구팀) ;
- 김현주 (한국과학기술연구원, 독성연구팀) ;
- 정상운 (한국과학기술연구원, 독성연구팀) ;
- 김명국 (동국제약 주식회사) ;
- 박희석 (동국제약 주식회사) ;
- 김용해 (한국과학기술원)
- Published : 1998.09.01
Abstract
The acute and genetic toxicity of DK1002 was subjected in this study. DK1002 which is a morphine-like new drug candidate synthesized by Dong-Kook Pharmaceutical Co. Ltd. is now under developing as a analgesics that have better drug efficacy and least addictive property. In acute toxicity study, the 50% lethal doses (
Keywords
- Acute toxicity;
- Salmonella typhimurium reversion assay;
- In vitro Chromosome aberration assay;
- In vivo Micronucleus assay;
- Analgesics;
- DK1002