Toxicological Research
- Volume 14 Issue 3
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- Pages.365-370
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Effects of the Administration of p-{N ,N-Bis(2-chloroethyl)amino}-4-phenyl acetyl-amino-2,6-piperidinedione (ck-15) on Rat Kidney
- Park, Sun-Hee (College of Pharmacy and Institute for Drug Development, Chonnam National University) ;
- Choi, Bo-Kil (College of Pharmacy and Institute for Drug Development, Chonnam National University) ;
- Lim, Dong-Koo (College of Pharmacy and Institute for Drug Development, Chonnam National University) ;
- ,
- Published : 1998.09.01
Abstract
To evaluate the renal toxicity of the antitumor agent, p-{N,N,-Bis(2-chloroethyl)amino}-4-phenyl acetyl-amino-2,6-piperidinedione(CK-15), rats were treated with CK-15 (acute: 50mg/kg. i.p., single and subacute: 5mg/kg, i.p., daily for 7 days). The changes in the body weight, water consumption, kidney weights and urine volume after and during the treatment were observed. The concentrations of urinary creatinine and portein, the activities of N-acetyl-
Keywords
- CK-15;
- Creatinine;
- N-acetyl-${\beta}$-D-glucosaminidase;
- Alanine aminopeptidase;
- ${\gamma}$-Glutamyltranspeptidase;
- Lactate Dehydrogenase