대한핵의학회지 (The Korean Journal of Nuclear Medicine)
- 제32권4호
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- Pages.305-313
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- 1998
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- 1225-6714(pISSN)
Tc-99m Galactosylated Serum Albumin (GSA)을 이용한 정량적 간수용체 영상술
Quantitative Evaluation of Liver Function with Hepatic Receptor Scintigraphy using Tc-99m Galactosylated Serum Albumin (GSA)
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이재태
(경북대학교 의과대학 핵의학교실)
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Lee, Jae-Tae
(Department of Nuclear Medicine, Kyungpook National University Hospital)
- 발행 : 1998.08.31
초록
The reduction in the amount of asialoglycoprotein (ASGP) receptor, which resides exclusively on the plasma membrane of functioning mammalian hepatocytes, as a consequence of hepato-cellular damage has been demonstrated in various pathologic conditions of the liver. Galac-tosylated human serum albumin (GSA) is a newly developed receptor-binding agent, specific for the ASGP receptor. Tc-99m GSA binds quantitatively to liver ASGP receptors and the rate of accumulation in the liver is dependent on hepatic function represented as the amount of receptor, as well as the amount of ligand injected, its affinity to the receptor and the hepatic blood flow. The findings of Tc-99m GSA scintigraphy were reported to reflect the hepatic function of the patients with large hepatic tumors, obstructive jaundice, acute and chronic liver disease. Tc-99m GSA scintigraphy is an easy and reliable test and has the clinical potentials to evaluate the liver function in the patients with hepatic disorders.
키워드