Clinical and Experimental Reproductive Medicine
- Volume 25 Issue 3
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- Pages.305-313
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- 1998
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
Effect of Steroid Hormones on the Expression of c-Fos, CREB, ATF, and HSP70 in Rat Uterus
흰쥐 자궁에서 스테로이드호르몬에 의한 c-Fos, CREB, ATF 및 HSP70의 발현에 관한 연구
- Lee, Young-Ki (Department of Medicine and Division of Molecular Biology, Ewha Medical Research Center, College of Medicine, Ewha Womans University) ;
- Kim, Sung-Rye (Dept of Histology, College of Medicine, Cheju National University)
- Published : 1998.09.30
Abstract
Steroid hormone is known to cause the dynamic changes of mammalian uterus during reproductive cycle. However there is little information about the effect of estrogen (E) and progesterone (P) on the expression of various transcription factors involved in gene expression. Thus the present study was designed to demonstrate E and/or P-induced expression of c-Fos, CREB, ATF and HSP70 in rat uterus. Rats, ovariectomized (OVX) for two weeks, were divided into 6 experimental groups, 1) OVX, 2) OVX+V, 3) OVX+E, 4) OVX+P, 5) OVX+E+V, 6) OVX+E+P, and western blotting assay for nuclear extract and immunohistochemical staining were carried out for each experimental group. Treatment of E
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