Toxicological Research
- Volume 14 Issue 4
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- Pages.541-545
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Comparison with Some Antioxidants on Hydroxyl Radical in Mouse Whole Brain Culture
- Lee, Jeong-Chae (Department of Bioactive Substances, Institute of Biotechnology, Chonnam National University) ;
- Lim, Kye-Taek (Department of Bioactive Substances, Institute of Biotechnology, Chonnam National University) ;
- Lee, Ki-Seoup (Department of Bioactive Substances, Institute of Biotechnology, Chonnam National University) ;
- Jung, Hee-young (Department of Bioactive Substances, Institute of Biotechnology, Chonnam National University)
- Published : 1998.12.01
Abstract
This experiment carried out to compare the protective effects of some antioxidants to hydroxyl radicals in embryonic mouse whole brain tissue culture. The ICR mouse whole brain (13 embryonic day) was cultured in hydroxyl radical system in which radicals were generated by 20 mU / ml glucose oxidase (GO). In this experiment, to make ferrous iron from ferric iron, iron as an accelerator, and ascorbic acid as a reductant were used. For comparison of the protective effects to hydroxyl radicals, antioxidants such as desferrioxamine (DFX), laccase. water or ethanol extracts from Rhus Vemiciflua Stokes (RVS), and