Acute Oral Toxicity of A Novel Combined Antibiotic(Cefatrizine / Clavulanic Acid) in Rats

  • Kwon, Jong-Won (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
  • Kang, Kyung-Koo (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
  • Hyun Cho (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
  • Baik, Nam-Gi (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
  • Ahn, Byoung-Ok (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
  • Kim, Gye-Won (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
  • Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co. Ltd.)
  • Published : 1998.12.01

Abstract

The acute toxicity study of combined antibiotic (Cefatrizine / Clavulanic Acid), a formulation consisting of cafatrizine and clavulanic acid in a ratio of 2 : 1, was evaluated in rats. The antibiotic was orally administered with single dose in dose levels up to 5 g/kg (0, 1.25, 2.5, 5 g/kg). Treatment-related effects were limited to soft stool excretion and caecal dilatation, but histologically no morphological changes could be detected in caecum. In hematology, serum-chemistry parameters and histopathology, no drug-related changes were found. The results of the present study indicate that cefatrizine / clavulanic acid has a low toxic potential and the oral $LD_{50}$values exceed 5 g / kg in rats

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