Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Four-Week Topical Toxicity Studies of SDK in Beagle Dogs and Sprague-Dawley Rats

비글개와 랫드에서 SDK시제품(가칭)의 4주간 피부도포 반복투여 독성시험에 관한 연구

  • 이원우 (서울대학교 수의과대학 공중보건학교실) ;
  • 임종희 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지윤 (서울대학교 수의과대학 공중보건학교실) ;
  • 남정석 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 이광훈 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 이학모 (서울대학교 수의과대학 공중보건학교실) ;
  • 이병희 (서울대학교 수의과대학 공중보건학교실)
  • Published : 1998.06.01
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Abstract

SDK (skin decontamination kit) is new skin decontaminant which is developed by ADD (Agency for defence development). In this study, four-week toxicity of SDK was investigated using beagle dogs and Sprague-Dawley rats. The beagle dogs and Sprague-Dawley rats were dressed topically seven days per week for 28 days, with dosage of 0, 0.25, 0.8 and 1 g/kg/day. respectively. Animals treated with SDK did not cause any death and show any clinical signs. They did not show any significant changes of body weight, feed uptake and water consumption. They were not significantly different from the control group in urinalysis, ocular examination and histopathological examination. In hematological and serum biochemical assay, there were no-dose-defendent changes. Therefore, SDK was not indicated to have any toxic effect in the beagle dogs and Sprague-Dawley rats when it was dressed topically below the dosage 1 g/kg/day for four weeks.

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