대한기관식도과학회지 (Korean Journal of Bronchoesophagology)
- 제4권2호
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- Pages.197-204
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- 1998
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- 1226-0916(pISSN)
후두편평세포암종에서 인유두종 바이러스의 검출
Detection of Human Papillomavirus in Laryngeal Squamous Cell Carcinomas
초록
Human papillomavirus(HPV) is epitheliotrophic virus invading the anogenital tract and the upper aerodigestive tract HRV produces a diversity of benign and maljgnant tumors. In this study, the author determined the frequency of association of human papillomavirus(HPV) and laryngeal carcinomas and investigated the significance of HRV infection of different subtypes in the tumorigenesis of laryngeal carcinoma. Laryngeal squamous cell cancinomas from 34 patients who did not have preexisting papillomas by clinical history were retrieved from formalin-fixed, paraffin-embedded blocks and analyzed for HPV. Nineteen cases were tumors of the true vocal folds, 11 were supraglottic and 4 were transglottic. HPV detection was dane using polymerase chain reaction amplification with HPV L