한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)
- 제18권2호
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- Pages.104-108
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- 1998
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- 1225-6307(pISSN)
한국산 생약으로부터 항암물질의 개발 (제9보). 비색분석법에 의한 포공령 추출물의 항암평가
Development of Anticancer Agents from Korean Medicinal Plants. Part 9. Antitumor Evaluation of Taraxaci Herba Extracts by Colormetric Methods.
초록
In the present study, we have evaluated cytotoxic effects of Taraxaci Herba extract in human oral epitheloid carcinoma cells. An antitumor activity was measured by colorimetric assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine protein B (SRB). The light microscopic study showed morphological changes, Ag-NOR (argyrophylic nucleolar organizer region) number and PAS positive reaction or the treated cells. These results obtained are as follows : MTT and SRB quantities were significantly decreased in cultured KB cells treated with 10