Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)
- Volume 18 Issue 2
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- Pages.77-82
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- 1998
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- 1225-6307(pISSN)
Antigenotoxicity of Galangin and its Action Mechanism
Galangin의 유전독성 억제효과와 작용기전
Abstract
In order to compare the suppressive effect of galangin on the genotoxicity by N-methyl-N-nitrosourea (MNU) or benzo[a]pyrene B(a)P, in vivo micronycleus test using mouse peripheral blood and in vitro sister chromatid exchange(SCE) test using mouse spleen lymphocytes were performed. MNU or B(a)P-induced micronucleated reticulocytes in vivo was decreased by the simultaneous treatment of galangin. MNU or B(a)P-induced SCEs in vitro was also decreased by the simultaneous treatment of galangin. On the other hand, the determinations of [
Keywords
- Galangin;
- Peripheral blood micronucleus assay;
- Sister chromatid exchange;
- DNA binding;
- DNA methylation;
- Alkylating agent;
- N-nitro-N-nitrosourea(MNU);
- Benzo(a)pyrene;
- Cancer chemopreventive agent