Cytogenic Effects of Transplacentally Administered 2-Bromopropane -Pattern of Replicative DNA Synthesis(RDS) by BrdU Labeling Method-

2-Bromopropane의 경태반 영향에 관한 연구 -마우스 태자로의 이행과 태자세포의 복제 DNA합성세포에 관하여-

2-Bromopropane has been implicated to be the reason for the mass intoxication of workers at an electronic company in Korea. 2-Bromopropane deposition and pattern of DNA replication in mouse fetuses were analyzed after intravenous injection of 2-bromopropane. Injections were administered to pregnant ICR mice in order to cytogenetically evaluate transplacental 2-bromopropane. The results are summarized as follows; 1. A dose-dependent effect on DNA replication was observed equally in the lung, liver and kideneys of fetuses has been exposed to 2-bromopropane transplacentally as reductions of the labeling index. 2. Deposition of transplacentally administred 2-bromopropane in the fetus was lower than placenta.