Nutritional Sciences
- Volume 1 Issue 1
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- Pages.22-28
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- 1998
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- 1229-232X(pISSN)
Plasma Concentrations of Vitamins E and A, and Effects of Vitamin E Supplementation on Oxidative Stress and Immune Status in Korean Non-Insulin Dependent Diabetic Patients
- Kim, Woo-Kyung (Department of Food and Nutrition, Dankook University) ;
- Park, Ock-Jin (Department of Food and Nutrition, Hannam University)
- Published : 1998.11.01
Abstract
Plasma concentrations of Vitamins E and A were measured in 15 non-insulin dependent Korean female subjects and 15 age-matched normal subjects using reversed-phase high-performance liquid chromatography. No differences were found in plasma Vitamin E concentrations between the 2 groups. Plasma Vitamin A concentrations were higher in subjects with non-insulin dependent diabetes melitus (NIDDM). The effects were evaluated of 4 weeks of daily supplementation of 400 mg Vitamin E on plasma levels of these two vitamins. In addition, the effects were observed for Vitamin E supplementation on oxidative stress and immune-related compound productions in non-insulin dependent diabetic patients and control subjects. After treatment with Vitamin E, plasma Vitamin E concentrations were significantly elevated in both groups. Basal plasma thiobarbituric acid reactive substances (TBABS) were identical, and a decreased level of TBARS caused by Vitamin E was observed only in the diabetic group (0.02739