랫트에서 한국형유산균인 Bifidobacterium breve K-110, K-111 및 infantis K-525 균주제제의 경구투여 급성독성

Acute Oral Toxicity of Bifidobacterium breve K-110 K-111 and B. infantis K-525 Isolated from Korean Intestine in Rats

Acute oral toxicity of Bifidobacterium breve K-110, Bifidobacterium breve K-111, Bifidobacterium infantis K-525 were studied in Sprague-Dawley rats of both sexes. In this study, we examined number of deaths, clinical signs, bod weight and gross findings for 14 day after single oral administration of B. breve K-110,B. breve K-111 or B. infantis K-525 with different levels. They did not show any toxic effect in rats and oral LD$_{50}$ value was over 5 g/kg in rats.s.