Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effect of MCT (medium-chain triglyceride) and LCT (long-chain triglyceride) on Myocardial Ischemia/Reperfusion Injury and Platelet Aggregation in Rat

MCT(medium-chain triglyceride) 및 LCT(long-chain triglyceride) 유제가 백서에서 허혈/재관류 심장기능손상 및 혈소판응집능에 미치는 영향

  • Lee, Soo-Hwan (Department of Physiology, School of Medicine, Ajou University) ;
  • Jung, Yi-Sook (Department of Physiology, School of Medicine, Ajou University) ;
  • Hong, Jeong (Department of Surgery, School of Medicine, Ajou University) ;
  • Kim, Min-Hwa (Department of Physiology, School of Medicine, Ajou University) ;
  • Lee, Hee-Joo (Department of Physiology, School of Medicine, Ajou University) ;
  • Baik, Eun-Joo (Department of Physiology, School of Medicine, Ajou University) ;
  • Wang, Hee-Jung (Department of Surgery, School of Medicine, Ajou University) ;
  • Kim, Myung-Wook (Department of Surgery, School of Medicine, Ajou University) ;
  • Moon, Chang-Hyun (Department of Physiology, School of Medicine, Ajou University)
  • 이수환 (아주대학교 의과대학 생리학교실) ;
  • 정이숙 (아주대학교 의과대학 생리학교실) ;
  • 홍정 (아주대학교 의과대학 일반외과학교실) ;
  • 김민화 (아주대학교 의과대학 생리학교실) ;
  • 이희주 (아주대학교 외과대학 생리학교실) ;
  • 백은주 (아주대학교 의과대학 생리학교실) ;
  • 왕희정 (아주대학교 의과대학 일반외과학교실) ;
  • 김명욱 (아주대학교 의과대학 일반외과학교실) ;
  • 문창현 (아주대학교 외과대학 생리학교실)
  • Published : 1998.12.01
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Abstract

Intravenous lipid emulsion is used extensively as a major component of parenteral nutrition for patients in the surgical intensive care unit. Abnormal cardiovascular function related to lipid infusion has been reported although conflicting results exist. In the present study, we investigated the effects of intravenous emulsions of long-chain triglyceride (LCT) and medium-chain triglyceride (MCT) on myocardial ischemia/ reperfusion injury and on platelet aggregation in rat. There was no difference between LCT and MCT considering the effects on left ventricular developed pressure (LVDP) and coronary flow rate (CFR) before and after ischemia/reperfusion in isolated rat heart. On the other hand, a difference was found between LCT and MCT with regard to their effects on heart rate (HR) and end diastolic pressure (EDP) after ischemia/reperfusion. After ischemia/reperfusion, HR was significantly (P<0.05) reduced and EDP significantly (P<0.05) inc.eased by LCT (18$\pm$2.0% and 42.8$\pm$8.9%, respectively), but not by MCT Ex vivo platelet aggregation induced by collagen was reduced by LCT infusion, but not by MCT These findings suggest that MCT may have slightly more favorable effect than LCT on the myocardial function after ischemia/reperfusion in rat.

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