Studies on the Antiinflammatory Effects of Natural Products

천연물의 항염증작용에 관한 연구

  • 유태무 (식품의약품안전청 국립독성연구소 약리부) ;
  • 이숙영 (식품의약품안전청 국립독성연구소 약리부) ;
  • 정수연 (식품의약품안전청 국립독성연구소 약리부) ;
  • 승상애 (식품의약품안전청 국립독성연구소 약리부) ;
  • 류항묵 (식품의약품안전청 국립독성연구소 약리부) ;
  • 양지선 (식품의약품안전청 국립독성연구소 약리부) ;
  • 이은방 (서울대학교 천연물과학연구소)
  • Published : 1998.09.01

Abstract

These studies were conducted to investigate the antiinflammatory effects and the mechanism of action of natural products. We used the methods of "carrageenan induced foot edema" , "PAF (platelet activating factor) induced foot edema" , "inhibition test of vascular permeability" , "inhibition test of white blood cell migration" , "formation of granuloma" and "adjuvant induced arthritis" to examine the antiinflammatory erects of Angelica gigas, Ledebouriella seseloides, Ginkgo biloba and Bamboo salt (Jukyom). The oral administration of the water extract of Angelica gigantis radix, the methanolic extract of Ginkgo folium and the aqueous solution of Bamboo salt showed antiinflammatory effect on carrageenan and PAF induced foot edema in SD rat at a dose of 1 g/kg. The same administration of methanolic extract of Ginkgo folium also inhibited the vascular permeability in mice. The aqueous solution of Bamboo salt inhibited the formation of ganuloma in SD rats at a oral dose of 1 g/kg. Angelica gigantis radix seems to have antiinflammatory effect by inhibition of PAF.

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