MK-801 투여에 의한 몰핀의존성랫드 뇌선초체중 도파민신경절달물질의 변화

Changes of the Extracellular Concentrations of Striatal Dopamine and Its Metabolites by MK-801 in Morphine-Dependent Rats

  • 이선희 (식품의약훔안전본부 독성연구소 특수독성과) ;
  • 신대섭 (식품의약훔안전본부 독성연구소 특수독성과) ;
  • 유영아 (식품의약훔안전본부 독성연구소 특수독성과) ;
  • 류승렬 (식품의약훔안전본부 독성연구소 특수독성과) ;
  • 김대병 (식품의약훔안전본부 독성연구소 특수독성과)
  • 발행 : 1998.03.01

초록

The roles of dopamine(DA) and N-methyl-D-aspartate(NMDA) system in the development and expression of morphine dependence were investigated by monitoring the concentrations of extracellular DA and its metabolites by in vivo microdialysis and simultaneous observation of behavioral changes in morphine dependent rats. Extracellular DA level in caudate putamen of morphine-dependent rat was decreased and the concentrations of its metabolites, dihydroxy phenylacetic acid(DOPAC) and homovanillic acid(HVA), were increased during naloxone-precipitated withdrawal. DA contents were recovered to normal levels by pretreatment of MK-801, a noncompetitive NMDA receptor antagonist, which may explain the mechanism of diminishing effect of MK-801 on withdrawal symptoms in morphine-dependent rats. MK-801(0.3 mg/tg, i.p.) induced the untoward hamful neurological signs such as ataxia and severe rotations, which may be produced by hyperactivation of dopaminergic system. These results suggest that MK-801 may inhibit the expression of mophine dependence by altering the dopamine release.

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