한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제15권1호
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  • Pages.116-123
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  • 1998
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

고양이 말초혈액 탐식세포의 탐식능에 있어서 인삼 사포닌의 효과

Effect of Ginseng Saponins on Phagocytosis of Feline Peripheral Blood Phagocytes

  • 발행 : 1998.03.01
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⟨ 이전 논문 다음 논문 ⟩

초록

고양이 말초혈액 탐식세포(단핵구세포(MNC) 및 다형핵백혈구(PMNC))의 탐식능 에 있어서 인삼 saponin(ginseng total saponin(G75), ginseng PT saponin(GPT) 및 ginseng PD saponin(GPD))의 면역증강 효과를 flow cytometry를 이용하여 분석하였다. 인삼 ssponins을 직접 첨가하여 배양한 MNC 및 PMNC에서는 탐식중강 효과가 나타나지 않았다. 각각의 인삼 saponin을 첨가하여 배양한 PMNC 및 MNC 배양상충액의 존재하에 PMNC 및 MNC의 탐식능을 겅토한 결과, MNC의 탐식능은 Gff 첨가 PMNC 배양상충액과 GTS 및 GPT 첨가 MNC 배양상충액의 존재하에서 약간의 탐식증강 효과를 보였다. PMNC 탐식능의 경우에는 GPD 첨가 PMNC 배양상충액에서 미약한 탐식증강 효과가 나타났으나, 각각의 인 삼 saponin 첨가 MNC 배양상충액 존재하에서는 모두 현저한 탐식중강 효과를 나타내었다. 이상의 결과로부터 고양이 말초혈액 탐식세포의 탐식증강 효과는 인삼 saponin의 직접적인 작용보다는 인삼 saponin에 의해 활성화된 단핵구세포에서 분비되는 가용성물질에 의해 단 핵구세포보다는 다형핵백혈구에서 현저하게 탐식효과가 증강되는 것으로 판단되었다.

키워드

참고문헌

  1. Arch Biochem Biophys v.292 Cytokines: from clone to clinic Aggarwal BB;Pocsik E
  2. Infect Immun v.55 Enhancement of resistance to Escherichia coli infection in mice by dihydroheptaprenol, a synthetic polyprenol derivative Araki S;Kagaya K;Kitoh K;Kimura M;Fukazawa Y
  3. J Vet Med Sci v.55 Effect of active egg white product on neutrophil function in weaning piglets Araki S;Kimura M;Suzuki M;Fujimoto M
  4. Am Rev Phamac v.9 New substances of plant origin which increase nonspecific resistance Brekhman Ⅱ;Dardymov Ⅳ
  5. J Immunol v.147 Differential effects of neutrophil-activating peptide 1/IL-8 and its homologoues on leukocyte adhesion and phagocytosis Detmers PA;Powell DE;Waltz A;Clark IL;Baggiolini M;Cohn ZA
  6. Biochem J v.264 Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils Dewald B;Thelen M;Wymann MP;Baggiolini M
  7. Granulocyte responses to cytokines Activation on neutrophils by interleukins-a and -2 and tumor necrosis factors Ferrante A;Coffey RG
  8. Advences in experimental medicine and biology v.319 Immunomodulatory drugs of relevance to the management of microbial infections Hersh EM;Friedman H;Klein TW;Yamaguchi H
  9. Journal of Neuroimmunology v.60 Enhancement of phagocytosis by dynorphin A in mouse peritoneal macrophages Ichinose M;Asai M;Sawada M
  10. Scandinavian Journal of Immunology v.42 beta-endorphin enhances phagocytosis of latex particles in mouse peritoneal macrophages Ichinose M;Asai M;Sawada M
  11. Cell Immunol v.156 A flow cytometric assay reveals an enhancement of phagocytosis by platelet activating factor in murine peritoneal macrophages Ichinose M;Hara N;Sawada M;Maeno T
  12. J Ethnopharmacol v.36 Recent advances on ginseng reserch in China Liu CX;Xiao PG
  13. J Vet Med Sci v.55 Effect of active egg white product on neutrophil function in calves Nakagawa J;Osame S;Ichijyo S;Araki S;Kimura M
  14. Journal of Surgical Research v.56 Studies of human granulocyte phagocytosis stimulation by tuftsin Nishioka K;Wagle JR;Rodriguez T Jr.;Maeta M;Kubo S;Dessens SE
  15. Infec Immun v.55 Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-1α Ozaki Y;Ohashi T;Minami A;Nakamura S
  16. Ad Vet Sci Comp Med Mechanisms of action of some immunomodulators used in veterinary medicine. Immunomodulation in domestic food animals Quinn PJ
  17. Am J Vet Res v.46 Effect of human leukocyte a interferon on prevention of infectious bovine rhinotracheitis virus infection of cattle Roney CS;Rossi CR;Smith PC;Lauerman LC;Spano JS;Hanrahan LA;William JC
  18. Am J Vet Res v.51 Influence of recombinant human interleukin 2 adminstration on lymphocyte and neutrophil function in clinically normal and dexamethazone-treated cattle Roth JA;Abruzzini AF;Frank DE
  19. Nature(Lond.) v.305 Functional identity between γ murine interferon and macrophage activating factor Schultz RM;Kleinshmidt NJ
  20. Immunology and Serology in Laboratory Medicine(2nd ed.) Turgeon ML
  21. Science v.236 The basis for the immunoregulatory role of macrophages and other accrssory cells Unanue ER;Allen PM
  22. Infec Immun v.55 Inhibition of the intracelluar growth of Histoplasma capsulatum by recombinant murine gamma interferon Wu-hsieh BB;Howard DH
  23. 인삼효능·제품연구결과요약집 제1집 박명규