한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제15권1호
  • /
  • Pages.83-93
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  • 1998
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Estrogen투여가 임신 rat에 미치는 영향

The Effect of Exogenous Estrogen on the Pregnant Rats

  • 김영흥 (경북대학교 수의과대학) ;
  • 송문용 (경북대학교 수의과대학)
  • 발행 : 1998.03.01
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초록

The purposes of the present study were to evaluate the effect of estrone on the prevention of implantation and pregnancy and the concentrations of estradiol and progesterone or sodium and potassium in the plasma or uterine fluid of pregnant rats injected a single dose of 0, 0.1, 0.4 or 1.0 mg on days 5, 9, or 13 of pregnancy. The body weight gains of pregnant rats were significantly decreased in administering estrone on day 5 of pregnancyi no effect obtained on days 9 or 13. Numbers of viable fetuses were significantly decreased and pre- and post-implantation loss increased by administering estrone 0.1, 0.4 or 1.0 mg and numbers of implantation sites significantly increased by administering estrone 0.1 mg but significantly decreased or not occurred by 0.4 or 1.0 mg on day 5 of pregnancy, respectively, but no effect obtained on days 9 or 13. Plasma estradiol concentrations of pregnant rats were significantly increased on 1, 2 or 18 days after treatment with estrone (1.4 or 1.0 mg and 3 days after 0.4 mg on day 5 of pregnancy, respectively. But plasma progesterone concentrations had no effect on the treatment with estrone. Plasma sodium contents were significantly increased on 1 day after treatment with estrone 0.1 or 1.0 mg and 3 days after 0.1 mg on day 5 of pregnancy, respectively, except potassium content were no detectable change. Sodium contents in uterine fluid were significantly increased on 1 day after treatment with estrone 1.0 mg and 3 days after 0.1, 0.4 or 1.0 mg on day 5 of pregnancy, respectively. And potassium contents were significantly increased on 1 or 2 days after treatments with estrone 0.1 mg but significantly decreased on 3 days after 0.4 or 1.0 mg on day 5 of pregnancy, respectively. It is suggested that the prevention of implantation and failure of pregnancy could be induced by treatment with estrone 0.4 mg on day 5 of pregnancy and might be interrelated with changes of plasma estradiol concentration and sodium and potassium contents in uterine fluid.

키워드

참고문헌

  1. J Reprod Fert v.90 Critical progesterone requirement for maintenance of pregnancy in ovariectomized rats Arkaravichien W;Kendle KE
  2. J Reprod Fert v.42 Pregnancy-terminating effect of human chorionic gonadotrophin in rats Banik UK
  3. J Endocr v.53 Plasma and pituitary luteinizing hormone concentrations and peripheral plasma estradiol concentration during early pregnancy and after the administration of progestational steroids in the rat Brown-Grant K;Corker CS;Naftolin F
  4. Endocrinology v.95 Serum estradiol and prolactin concentrations in neonatal female rats treated with human chorionic gonadotrophin(HCG) Cheng HC;Johnson DC
  5. J Endocr v.59 The sodium and potassium content of rat uterine luminal fluid Conner EA;Miller JW
  6. Contraception v.6 Rat uterine fluid electrolytes and the estrous cycle de Jesus TPS;Mallikarjuneswar VR;Clemeston CAB
  7. J Endocr v.18 The effects of steroid sex hormones on pregnant rats Dreisbach RH
  8. Fertil Steril v.12 A guantitative study of the termination of pregnancy in rats with estrone Edgren RA;Shipley GC
  9. J Reprod Fertil v.3 Local and parenteral action of estrogens and anti-estrogens on early pregnancy in the rat and mouse Emmens CW;Finn CA
  10. Biol Reprod v.24 Ovum transport in pregnant, Pseudopregnant, and cyclic rats and its relationship to estradiol and progesterone blood levels Forcelledo ML;Vera R;Croxatto HB
  11. Anesthesiology v.65 Reproductive and teratogenic effects of lidocaine in Sprague-Dawley rats Fujinaga M;Mazze RI
  12. Endocrinology v.69 The anti-fertility effects in pregnant rats of a single injection of estradiol cyclopentylpropionate Greenwald SG
  13. Anat Rec v.157 Species differences in egg transport in response to exogenous estrogen Greenwald GS
  14. J Reprod Fert v.13 Plasma progesterone concentrations during pregnancy and lactation in the rat Grota LJ;Eik-Nes KB
  15. Anat Rec v.162 Interference with early pregnancy in rats by estrogen: Mechanism of action of Dienestrol Harper MJK
  16. J Cell Physiol v.62 Electrolyte analyses of chick embryonic fluids and heart tissues Harsh M;Green JW
  17. J Endocr v.25 The influence of ovarian hormones on some chemical constitutions of the uterine washing of rats and rabbits Heap RB;Lamming GE
  18. Am J Physiol v.196 no.1 Potassium and sodium content of uterine and seminal vesicle secretions Howard E;Defeo VJ
  19. Endocrinology v.90 Acute effect of gonadotrophins on the secretion of progestins by the rat ovary Ichikawa S;Morioka H;Sawada T
  20. Teratology v.29 Maternal toxicity: A possible factor in fetal malformations in mice Khera KS
  21. Teratology v.31 Maternal toxicity: A possible etiological factor in embryo-fetal defects and fetal malformations of rodents-rabbits species Khera KS
  22. Biol Reprod v.10 Temporal relationship between secretory patterns of gonadotrophins, estrogens, progestins, and prostaglandin F in periparturient rats Labhsetwar AP;Watson DJ
  23. J Endocrin v.29 Effects of combinations of progesterone and estrone on the delay of nidation, implantation and fetal survival in ovariectomized rats Mayer RK;Nutting EF
  24. J Reprod Fert Suppl v.180 Endocrinology of implantation McLaren A
  25. Biol Reprod v.19 Effects of placental luteotrophin and estrogen on the growth of artificially formed secondary corpora lutea of pregnancy in rats Nakamura Y;Ichikawa S
  26. Gynecol Obstet Invest v.28 Influence of progesterone on the sodium and potassium concentrations of rat uterine fluid investigated by microdialysis Nordenvall M;Ulmsten U;Ungerstedt U
  27. Am J Obstet v.115 no.2 The content of calcium, magnesium, copper, iron, sodium, and potassium in amniotic fluid from eleven to nineteen weeks' gestation Nusbaum MJ;Zettner A
  28. J Endocrin v.29 Effects of estrone on the delay of nidation, implantation and fetal survival on ovariectomzied rats Nutting EF;Meyer RH
  29. Endocrinology v.74 Effects of various steroids on nidation and fetal survival in ovariectomized rats Nutting EF;Meyer RK
  30. Endocrinology v.95 A comparative study of serum progesterone levels in pregnancy and in various types of pseudopregnancy in the rat Pepe GJ;Rothchild I
  31. Endocrinology v.86 Hormonal control of gestation in the intact rat Ray HGM;Mougal NR
  32. Endocrinology v.68 The composition of rat uterine luminal fluid Ringer I
  33. Endocrinology v.77 Effects on the course of pregnancy of Norethynodrel with Mestranol(Enovid) administered to rat during early pregnancy Saunders FJ
  34. Endocrinology v.78 Luteolytic effect of LH and HCG on the corpora lutea of pseudo-pregnant rabbits Spies HG;Coon LL;Gier HT
  35. Biol Reprod v.25 In vivo and vitro ovarian steroidogenesis in the pregnant rat Taya K;Greenwald GS
  36. J Endocr v.65 Plasma hormones and pituitary luteinizing hormone in the during the early stages of pregnancy and after post-coital treatment with Tamoxifen(ICI 46474) Watson J;Anderson FB;Alam M;O'Grady JE;Heald PJ
  37. Endocrinology v.82 Progesterone catalolism in the rat ovary: A regulatory mechanism for progestational potency during pregnancy Wiest WG;Kidwell WR;Balough K
  38. J Endocr v.51 Effects of estrogen and progesterone on the development, oviductal transport and uterine retention of eggs in hypophysectomzied pregnant rats Wu JT;Dickmann Z;Johnson DC
  39. Endocrinology v.83 Interruption of pregnancy in the rat and hamster by administration of PMS or HCG Yang WH;Chang ME
  40. Biol Reprod v.1 Prolonged gestation in the PMSG-treated immature rat Zarrow MX;Clark JH;Roelling C;Denenberg VH
  41. 한국수의공중보건학회지 v.18 no.3 임신랫트에 임마혈청성성선자극호르몬을 투여했을때 기형 발생 또는 태아흡수에 미치는 영향 김영홍;장인호;유창준;이근우
  42. 한국수의공중보건학회지 v.19 no.3 Ketamine투여가 임신랫트의 생식, 기형발생, 그리고 혈장, 양수 및 수태산물의 Na와 K 농도에 미치는 영향 김영홍;장인호;유창준;김성훈