Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Taurine Concentrations Are Closely Associated with Fatty Acids Concentrations in Breast Milk from Koreans

한국인 모유의 지방산 조성과 타우린 농도의 상관관계에 관한 연구

  • 박태선 (연세대학교 생활대학 식품영양학과)
  • Published : 1998.01.01
Download PDF
⟨ Previous Next ⟩

Abstract

Kong chain $\omega$3 & $\omega$6 fatty acids and taurine have been suggested to have structural and /or functional roles in the brain. The purpose of this study was to evaluate the changes in the percentage of fatty acids and taurine concentration in human milk obtained from Korean mothers(n=37) as lactation proceeds from birth to 5wks postpartum , and to determine the correlation between taurine concentration and fatty acid composition in breast milk. Level of fatty acids and taurine in breast milk were measured by GLC and HPLC, respectively. The percentages of medium -chain saturated fatty acids(10 : 0, 12 : 0 & 14: 0) were increased significantly , while percentages of long-chain saturated fatty acids(22 :0 & 24 : 0), and most of the long chain $\omega$6 and $\omega$3 fatty acids(20 : 3$\omega$6 , 20 :4$\omega$6, 22 :4$\omega$6 , 22 :5$\omega$6, 22 :5$\omega$3 & 22 : 6$\omega$3) were decreased significantly in mature milk (5 wks postpartum ) as compared to the colostrum. Taurine concentrations in colostrum and mature milk from Korean mothers were 549 $\pm$58 and 233 $\pm$41nmol/ml , respectively. Taurine concentrations in human milk was negatively correlated with the percentages of medium -chain saturated fatty acids ( 10 : 0 &12 : 0), and positively correlated with the percentages of long-chain saturated fatty acids( 16 :0, 20 : 0, 22 : 0& 24 : 0) and long-chain monounsaturated fatty acids( 20 : 1, 22 : 1 & 24 ; 1). Taurine concentration in human milk was positively correlated with elongation indices of both $\omega$6 and $\omega$3 fatty acids, and negatively correlated with the desaturation index of $\omega$6 fatty acids. These close relationships between fatty acids compositions and taurine level in human milk are worth pursing further investigation, especially with regard to their common roles in retina and brain development.

Keywords

References

  1. Nutrition in Pregnancy and Lactation(3rd ed.) Worthington-Roberts,B.S.;Vermeersch,J.;Williams,S.R.
  2. 한국영양학회지 v.27 no.6 모유와 유아용 조제분유의 지질 및 지방산 조성 임현숙;허영란
  3. 한국낙농학회지 v.7 모유와 우유의 지질에 관한 연구 Ⅰ. 중성 지질 함량 및 지방산 조성 차관종;황주환;유제현
  4. J Pediatr v.90 Fatty acid patterns of human milk Guthrie,H.A.;Picciano,M.F.;Sheehe,D.
  5. Am J Clin Nutr v.32 Effects of varying maternal dietary fatty acids in lactating women and their infants Mellies,M.J.;Ishikawa,T.T.;Gartside,P.S.;Burton,K.;MacGee,J.;Allen,K.;Steiner,P.M.;Brady,D.;Glueck,C.J.
  6. Am J Clin Nutr v.29 The effects of dietary fatty acids and cholesterol on the milk lipids of lactating women and the plasma cholesterol of breast-fed infants Potter,J.M.;Nestel,P.J.
  7. Lancet v.345 Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Makrides,M.;Neumann,M.;Simmer,K.;Pater,J.;Gibson,R.
  8. Neurosci Biobehav Rev v.16 Do essential fatty acids play a role on brain and behavioral development? Wainwright,P.E.
  9. Ann Rev Nutr v.8 The essentiality of n-3 fatty acids for the development and function of the retina and brain Neuringer,M.;Anderson.G.J.;Connor,W.E.
  10. J Pediatr v.120 Tissue levels of polyunsaturated fatty acids during early human development Martinez,M.
  11. J Am Diet Assoc v.93 Are n-3 fatty acids essential nutrients for fetal and infant development? Nettleton,J.A.
  12. Korean J Nutr v.29 no.8 Effect of dietary ω3 and ω6 fatty acids on the fatty acid composition of RBC and brain synaptosomal, microsomal and mitochondrial phospholipids and on behavioral development of rats Um,Y.S.;Chung,E.J.;Lee-Kim,Y.C.
  13. Invest Ophthalmol Vis Sci v.27 Polyunsaturated fatty acids and vitamin E in rat rod outer segments during light damage Wiegand,R.D.;Joel,C.D.;Rapp,L.M.;Nielsen,J.C.;Mande,M.B.;Anderson,R.E.
  14. Biol Neonate v.32 Is taurine essential for the neonates? Rigo,J.;Senterre,J.
  15. Pediatrics v.71 Feeding the low-birth-weight infant. Ⅱ. Effect of taurine and cholesterol supplementation on amino acids and cholesterol Rassin,K.;Gaull,G.E.;Jarvenpaa,A.L.;Raiha,N.C.R.
  16. J Pediatr v.116 Taurine depletion in very low birth weight infants receiving prolonged total parenteral nutrition : role of renal immaturity Zeilikonic,I.;Cheesney,R.W.;Firedman,A.L.;Ahfors,C.E.
  17. Nutr Today Taurine update : metabolism and function Picone,T.A.
  18. Physiol Rev v.72 Physiological actions if taurine Huxtable,R.J.
  19. J Neurosci Res v.13 Taurine deficiency in the developing cat : persistance of the cerebellar external granule cell layer Sturman,J.A.;Moretz,R.C.;French,J.H.;Wieniewski,H.M.
  20. Adv Exp Med Biol v.217 Nutritional taurine deficiency and feline preganancy and outcome Sturman,J.A.;Palackal,T.;Imaki,H.;Moretz,R.C.;French,J.;Wieniewski,H.M.
  21. J Neurosci Res v.15 Abnormal visual cortex development in the kitten associated with maternal dietary taurine deprivation Palackal,T.;Moretz,R.C.;French,J.;Wieniewski,H.;Sturman,J.A.
  22. J Neurosci Res v.11 Protective effect of taurine and zinc on peroxidation-induced damage jin photoreceptor outer segments Pasantes-Morales,H.;Cruz,C.
  23. Brain Res v.330 Taurine and hypotaurine in hibit light-induced lipid peroxidation and protect rod outer segments structure Pasantes-Morales,H.;Cruz,C.
  24. J Lipid Res v.27 Direct trans-esterification of all classes of lipids in a one step reaction Lepage,G.;Roy,G.C.
  25. Biochem J v.199 Amino acid analysis at the picomole level Chang,J.Y.;Knecht,R.;Braun,D.G.
  26. 한국식량영양학회지 v.11 인유 및 우유의 지방산 조성에 관하여 윤태헌;임경자;김을상;정우갑
  27. 한국식량영양학회지 v.14 수유기간의 경과에 따른 이유 트리글리세리드의 지방산 조성, 아실 탄소수 및 종의 변화 윤태헌;임경자
  28. 한국영양학회지 v.24 수유기간에 따른 모유의 성분함량 변화와 수유부의 섭식태도 및 영아의 성장발육에 관한 생태학적 연구-Ⅱ.모유의 지질 함량에 관한 연구 최문희;문수재;안홍석
  29. 한국영양학회지 v.29 no.2 한국인 수유부에 어유의 보충급여효과에 관한 연구-Ⅱ.모유의 지질 농도 및 지방산 조성에 미치는 영향 임현숙;이정아
  30. Lipids v.27 Human mammary gland function at the onset of lactation : Medium-chain fatty acid synthesis Spear,M.L.;Bitaman,J.;Hamosh,M.;Wood,D.L.;Gavula,D.;Hamosh,P.
  31. Am J Clin Nutr v.35 Breast milk composition : fat content and fatty acid in vegetarians non-vegetarians Finely,D.A.;Lonnerdal,B.;Dewey,K.G.;Grivetti,L.E.
  32. Am J Clin Nutr v.61 Changes in the polyunsaturated fatty acids breast milk from mothers of full term infants over 30week of lactation Makrides,M.;Simmer,K.;Neumann,M.;Gibson,R.
  33. J Pediatr v.120 The fatty acid composition of human milk in Europe and Africa Koletzko,B.;Theil,I.;Abiodum,P.O.
  34. Asia Pacific J Clin Nutr Relationship between fatty acid compositions and taurine concentration in breast milk from Chinese rural monthers Lee-Kim,Y.C.;Park,T.;Chung,E.J.;Um,Y.S.;Lei,S.;Xiang,M.;Li,T.
  35. Early Hum Dev v.18 Long-chain n-3 fatty acids in breast milk of Inuit women consuming traditional foods Innis,S.M.;Kuhnlein,H.V.
  36. Am J Clin Nutr v.41 Fatty acid composition of breast milk from three racial groups from Penang, Malaysia Kneebone,G.M.;Kneebone,R.;Gibson,R.A.
  37. Eur J Clin Nutr v.42 Fatty acid composition of human milk from South African black mothers consuming a traditional maize diet Beusekom,C.M.;Chetty,N.;Atkinson,P.M.
  38. Lipids v.31S Trans, n-3 and n-6 fatty acids in Canadian human milk Ratnayake,W.M.V.;Chen,Z.Y.
  39. J Nutr v.125 Milk composition in women from five different regions of China : The great diversity of milk fatty acids Chulei,R.;Xiaofang,L.;Hongsheng,M.;Xiulan,M.;Guizheng,L.;Gianhong,D.;DeFancesco,C.A.;Connor,W.E.
  40. J Pediatr Gastroentrol Nutr v.3 Lipid in Human milk : a review 1 : sampling, determination, and content Ferris,A.M.;Jensen,R.G.
  41. New Engl J Med v.315 A terrestrial souce of ω3 fatty acids Simopoulos,A.P.;Salem,J.
  42. 한국영양학회지 v.26 no.8 모유영양아의 수유기간별 taurine 섭취량에 관한 연구 김을상;이종숙;최경순;조금호;설민영;박미아;이규한;이영남;노희경
  43. 한국영양학회지 v.17 no.1 한국인 모유중 taurine 함량에 관한 연구 이종숙
  44. 한국영양학회지 v.22 no.1 한국인 채식주의자의 수유기간중 모유의 taurine 함량 변화 최경순;김을상
  45. Br J Nutr v.566 Taurine concentrations in the diet, plasma, urine and breast milk of vegans compared with omnivores Rana,S.K.;Sanders,T.A.B.
  46. Am J Clin Nutr v.30 Breast milk composition in Ethiopian and Swedish mother. Ⅲ Amino acids and other nitrogenous substances Svanberg,U.I.F.;Gebre-Medhin,M.;Ljunggvist,B.;Olsson,M.