Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effect of Vitamin E Supplementation on Lipid Distribution and Serum Insulin in Experimental Model Rats with Impaired Glucose Tolerance

내당능 장애 모델 흰쥐에서 Vitamin E의 과잉섭취가 지질 분포와 혈청 Insulin 농도변화에 미치는 영향

  • 이영주 (서울대학교 생활과학대학 식품영양학과)
  • Published : 1998.10.01
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Abstract

The aim of the study was to determine whether vitamin E supplementation in three experimental model rats with impaired glucse tolerance could change serum insulin concentration and lipid distribution. The three groups were adult(AS) and neonatal (NS) streptozotocin-induced groups, and a high sucrose diet(HS) group. Each group was divided into control and vitamin E supplementatino groups at the age of 9 weeks. The level of vitamin E supplementation was 5g/kg diet. Blood and organ samples were taken at 5 and 10 weeks and were examined for changes in the level of serum insulin, glucose, lipids, liver lipids, and oxidative status. Vitamin E supplementation significantly reduced serum insulin in the HS group and caused the significant beneficial changes in serum lipids and triglycerides in As grouop at 10 weeks . In all groups, serum vitamin E was increased and malondialdehyde(MDA) in serumand liver were decreased significantly by vitamin E supplementation. The results suggest that vitamin E supplementation improves lipid distribution in adult streptozotocin-induced rats and serum insulin concentration in high sucrose diet-induced rats. Vitamin E might prevent on reduce oxidative injury in all experimental model rats with impaired glucose tolerance.

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