Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Inhibition of Sarcoma-180 Cell-induced Mouse Ascites Cancer by Astaxanthin-containing Egg Yolks

Sarcoma-180 Cell로 유발한 Mouse 복수암에 대한 Astaxanthin 함유 난황의 효과

  • Published : 1998.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Anticarcinogenic activity of astaxanthin-contatining egg yolk(designate AEY) was investigated for mouse ascites carcinogenesis induced by mouse Sarcoma-180(S-180) cells. Female ICR mice(8mice/treatment, 7∼8weeks of age, 25±1g) were injected, i.p. with S-180 cells(1×107cell/ml PBS). Two days later, each mouse was given 0.1ml PBS containing AEY(10, 25 or 50ug/g body weight) or control egg yolk (CEY; 50ug/g body weight) every other day for 7 times. Control mice were only given 0.1ml S-180 cells and 0.1ml PBS. Mice treated with 25ug/g body weight of AEY showed 24.8 days of life, which was equivalent to 138% of control mice's life(180.0 dyas). Based on dose-dependant experiment of AFY, mice treated with 10ug/g body weight showed slightly longer life(19.4 days) relative to mice treated with control mice, and mice treated with 50ug/g body weight exhibited 21.9 days of life. Mice treated with any dose of AEY exhibited longer life than mice with CEY 50ug/g body weight. Body weight of mice treated with AEY was reduced relative to that of control mice CEY-treated mice. These results suggest than AEY inhibits the carcinogenesis of mouse ascites induced by S-180 cells.

Keywords

References

  1. J. Agric. Food Chem. v.37 Overestimation of the cholesterol content of eggs Beyer, R. S.;Jensen, L. S.
  2. J. Food Sci. Nutr. v.1 Beneficial effects of dietary anticarcinogenic conjugated linoleic acid(CLA) on the performances of laying hens and broilers Byon, J. I.;Park, S. J.;Park, K. A.;Ha, J. K.;Kim, J. O.;Ha, Y. L.
  3. Poultry Sci. v.70 Dietary modification of yolk lipid with mengaden oil Hargis, P. S.;Van Elswyk, M. E.;Hargis, B. M.
  4. Poyltry Sci. v.55 The cholesterol problem, the egg and lipid metabolism in the laying Naber, E. C.
  5. 88th AOCS Annual Meeting & Expo Effects of dietary conjugated linoleic acid on cholesterol content of egg tolks Ha, y. L.;Joo, Y. G.;Park, T. S.;Lee, J. I.;Kim, J. H.;Park, G. B.
  6. Poultry Sci. v.69 The effect of feeding lovastatin and colestipol on production and cholesterol content of eggs Luhman, C. M.;Miller, B. G.;Beitz, D. C.
  7. Poultry Sci. v.70 Research note: Effect of feeding garlic oil on performance and egg yolk cholesterol concentration Reddy, R. V.;Lightsey, S. F.;Maurice, D. V.
  8. Lipids v.18 Inhibition of cholesterol and fatty acid biosynthesis in liver enzymes and chicken hepatocytes by polarfraction of garlic Qureshi, A. A.;Abuirmrileh, N.;Din, Z. Z.;Elson, C. E.;Burger, W. C.
  9. J. Ferment. Bioengin. v.75 Improvement of astaxanthin production by Phaffia rhodozyma through mutation and optimization of culture conditions Fang, T. J.;Cheng, Y. S.
  10. Environmental Mutagens & Carcinogens v.17 Inhibition of DMBA-induced mouse epidermal carcinogenesis by astaxanthin-containing egg yolks Lee, S. H.;Park, C. W.;Lee, Y. C.;Choi, Y. S.;Ha, Y. L.
  11. Agric. Chem. Biotech. v.40 Inhibition of benzo[a]pyrene-in-duced mouse forestomach neoplasia by astaxanthin containing egg yolks Lee, S. H.;Park, C. W.;Park, W. S.;Lee, Y. C.;Choi, E. S.;Ha, Y. L.
  12. Agric. Chem. Biotech. v.4 Protent anticarcinogenic action of Moutan radix for mouse ascites cancer induced by mouse Sarcoma 180 cells Bahn, K. N.;Lee, E. J.;Yang, M. S.;Kim, J. O.;Ha, Y. L.
  13. Carcinogenesis v.16 Suppression of azoxymethane-induced rat colon carcinogenesis by dietary adminstration of naturally occurring xanthophylls, astaxanthin and canthaxanthin during the postiitation phase Tanaka, T.;Kawamori, T.;Ohnishi, M.;Makita, H.;Mori, H.;Satoh, K.;Hara, A.
  14. Cancer Res. Baltimore v.55 Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin Tanaka, T.;Makati, H.;Ohnishi, M.;Mori, H.;Satoh, K.;Hara, A.
  15. J. Fish Diseases v.18 Antioxidant status and immunity in Atlantic calmon, Salmon salar L., fed semi-purified diets with and without asaxanthin supplementation Christiansen, R.;Glette, J.;Lie, O.;Torrissen, O. J.;Waagbo, R.
  16. Nutr. Res. v.15 Astaxabthin: Antioxidant effects in chicken embryo fibroblasts Lalor, S. M.;O'brien, M. N.
  17. J. Nutr. Sci. Vitaminol. v.39 Inhibitory effect of beta-carotene and astaxanthin on photosensitized oxidation of phospholipid bilayers Oshima, S.;Ojima, F.;Sakamoto, H.;Ishiguro, Y.;Terao, J.
  18. Arch. Biochem. Biophys. v.297 Astaxathin and canthaxanthin are potent antioxidants in a membrane model Palozza, P.;Krinsky, N. L.
  19. J. Nutr. v.125 Astaxanthin, a carotenoid without vitamin A activity, augments antibody respinses in culture including T-helper cell colnes and suboptimal doses of antigen Jyonouchi, H.;Sun, S.;Tomita, Y.;Gross, M. D.
  20. Nutr. Cancer v.16 Studies of immunomodulating actions of carotenoids. 1. Effects of beta-carotene and astaxanthin on murine lympocyte functions and cell surface maker expression in in vitro culture system Jyonouchi, H.;Hill, R. J.;Tomita, Y.;Good, R. A.