한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)
- 제13권3호
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- Pages.232-237
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- 1998
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- 1229-1153(pISSN)
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- 2465-9223(eISSN)
UVB조사에 의한 Phenothiazine의 광독성에 미치는 Ascorbic Acid 의 영향
Effect of Ascorbic Acid on the Phototoxicity of Phenothiazines by UVB Irradiation
초록
광독성 및 광알러지를 일으키는 물질인 phenothiazine계 약물중 chlopromazine(CPZ), perphenazine(PPZ), trifluoperazine(TFZ), promethazine(PMZ)을 택하여 적혈구에서의 광용혈현상을 Kahn 등의 방법에 의하여 UVB(UV irradiation RMX-3W,
The purpose of this study is to examine the phototoxicity of four phenothiazine derivatives such as chlorpromazine, perphenazine, trifluoroperazine and promethazine, and to investigate the effects of ascorbic acid on their phototoxicity by UVB irradiation. Effects of the test compounds on RBCs were monitored with a spectrophotometer by the method of Kahn et al. The extent of photohemolysis by tested phenothiazine derivatives were increased with their concentration and toxic photoproducts were formed by chlorpromazine and promethazine with preirradiated UVB. Photohemolysis postirradiated chlorpromazine and perphenazine and preirradiated promethazine were decreased with the use of ascorbic acid significantly.