Korean Journal of Veterinary Pathology (한국수의병리학회지)
- Volume 2 Issue 1
- /
- Pages.47-52
- /
- 1998
- /
- 1226-766X(pISSN)
Histopathological observation of spontaneous testicular atrophy in Sprague-Dawley rat
Sprague-Dawley 랫트에 자연발생한 고환위축의 병리조직학적 관찰
- Son, Hwa-Young (Screening & Toxicolog Research Center, Korea Research Institute of Chemical Technology) ;
-
Kim, Yong-Bum
(Screening & Toxicolog Research Center, Korea Research Institute of Chemical Technology)
;
- Ha, Chang-Su (Screening & Toxicolog Research Center, Korea Research Institute of Chemical Technology) ;
- Kang, Boo-Hyon (Screening & Toxicolog Research Center, Korea Research Institute of Chemical Technology)
- 손화영 (한국화학연구소 스크리닝-안전성연구 센터) ;
-
김용범
(한국화학연구소 스크리닝-안전성연구 센터)
;
- 하창수 (한국화학연구소 스크리닝-안전성연구 센터) ;
- 강부현 (한국화학연구소 스크리닝-안전성연구 센터)
- Published : 1998.06.01
Abstract
The incidence of spontaneous testicular atrophy and its morphological changes during stage-specific spermatogenesis were investigated in male Sprague-Dawley rats at 10, 19, and 32 weeks of age. The incidence of testicular atrophy was 0.2%(2/90) 7.9%(9/114) and 10%(4/40) in 4, 13 and 26 weeks respectively. The epididymis with testicular atrophy had low sperm density. In the minimally affected tests scattered tubules showed complete depletion of germ cells without stage specificity. Testes with moderate to severe testicular atrophy showed seminiferous tubules lined with dense Sertoli cell population. While Leydig cells in the interstitium appeared hypertrophy they were immunohistochemically negative for proliferating cell nuclear antigen a marker of cell proliferation.