생명과학회지 (Journal of Life Science)

  • 제8권2호
  • /
  • Pages.167-172
  • /
  • 1998
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

흰쥐의 생리활성에 미치는 송엽(松葉) 추출물(PNE)의 영향 III. 뇌세포막의 유동성 및 신경전달관련 효소의 활성에 미치는 PNE의 투여효과

Effect of Pine Needle Extract (PNE) on Physilolgical Activity of SD Rats III. Feeding Effect of PNE on Fluidity and Neurotransmitter-Related Enztmes in Brain Membranes of SD Rats

  • 최진호 (부경대학교 식품생명과학과 생화학연구실) ;
  • 김정화 (부경대학교 식품생명과학과 생화학연구실) ;
  • 김동우 (부경대학교 식품생명과학과 생화학연구실) ;
  • 황찬호 (부경대학교 식품생명과학과 생화학연구실) ;
  • 김대익 (부경대학교 식품생명과학과 생화학연구실) ;
  • 이종수 (부경대학교 식품생명과학과 생화학연구실)
  • 발행 : 1998.04.01
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초록

To investigate the effect of pine needle extract (PNE) on membrane fluidirt and neurotransmiter-related enzymes in brain of Spragu-Dawley(SD), male SD rats were fed basic diets (control group), and experimantal diets (PNE group)with 0.5% and 0.1% fo PNE for 6 weeks. pine (pinus tabulaeformis C$_{ARR}$ is one of the popular plant drugs which has used as a medicine in Asia. Cholesterol levels in brain mitochondria of 0.5%-PNE and 0.1%-PNDE groups were significantly decreased in 15% and 25%, respectively, compared with control group, but cholesterol levels in brain microsomes of these PNE groups howed almost no change compared with control group. Lipofuscin accumulations in brain membranes of 0.5%-PNE and 0.1%-PNE groups were sgnificantly inhibited in 18% and 21%, respectively, compared with control group. Brain memberance fluidity was also activated in 50% and 100% by the administration of 0.5%-PNE and 0.1%-PNE. higher acetylcholinesterase(15% and25%) and lower monoamine oxidase B (25% and 15%0 activities were effectively modulated by the administration of 0.5%-PNE and 0.1%-PNDE. These results suggest that more beneficial effects such as inhibition of cholesterol and lipofuscin, increase of membrane fluidity, higher acetylcholinesterase and lower monoamone oxidase activities in brain membranes of SD rats may be effectively modulated by administration of pine needle extract (PNE).

키워드

참고문헌

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