Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지

Effects of Aerobic Exercise on Serum Lipid in Cholesterol-Dietary Rats

유산소성 운동이 콜레스테롤식이 흰쥐의 혈청지질에 미치는 효과

  • 김귀원 (부산대학교 사범대학 체육교육과) ;
  • 남태호 (부산대학교 사범대학 체육교육과) ;
  • 백영호 (부산대학교 사범대학 체육교육과)
  • Published : 1998.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Sprague Dawley rats(24 weeks of age) were divided and were given normal diet for 6 weeks, followed by normal diet and 2% cholesterol diet for 14 weeks. During these periods, 10 weeks’ exercises are performed after 4 weeks. And then we analyze the blood and adipose tissue by decapitating those rats. 1. Serum total cholesterol was enhenced by cholesterol diet, while aerobic exercise tended to reduce it. 2. Cholesterol diet slightly reduced serum HDL-C and LDL-c, where as aerobic exercise showed a tendency to decrease it. 3. Cholesterol diet slightly reduced phospholipid and triglyceride, but aerobic exercise showed a tendency to increase them. 4. Aerobic exercise significantly decreased adipose tissue in normal diet rats and tended to reduce it in cholesterol-dietary rats. These results suggest that aerobic exercise decrease serum total cholesterol and LDL-C, and as a result can prevent atherosclerosis.

본 연구는 생후 4주령의 Sprague Dawley 흰쥐 47마리를 대상으로 2% 콜레스테롤 식이와 정상식이 그리고 여러가지 강도의 유산소운동(트래드밀 런닝)과 비운동을 실시하여 혈청지질과 adipose tissue를 분석해서 다음과 같은 경과를 얻었다. 1. 콜레스테롤식이에 의해 형중T-C치가 유의하게 증가되었으나 유산소성운동에 의해 감소하는 경향을 나타내었다. 2. 콜레스테롤식이에 의해 혈중 HDL-C와 LDL이 약간 증가야였으나, 유산소성운동에 의해 모두 감소하는 경향을 나타내었다. LDL/HDL-C는 간한 운동을 한 CRA군에서만 감소하는 경향을 나타내었다. 3. 콜레스테롤식이에 의해 혈액중의 phospholipid 및 triglyceride는 감소하는 경향을 나태내었으나, 유산소성운동에 의해 약간 증가하는 경향을 나태내었다. 4. 정상식이군에서 유산소성운동에 의해 adipose tissue가 유의하게 감소되었으며, 콜레스테롤 식이군에서도 유산소성운동에 의해 adipdse tissue가 감소하는 경향을 나타내었다. 이상과 같은 연구결과를 통하여 유산소성운동이 콜레스테롤식이에 의해 증가도니 혈중 총콜레스테롤을 저하시키며, 동백경과 위험인자인 LDL은 낮추어 동맥경화성 질병을 예방할 것으로 사료된다.

Keywords

References

  1. 대한내과학회잡지 v.38 no.5 관상동맥질환의 위험인자 서정돈
  2. 효성여대박사학위논문 우유가 쥐의 혈청 Cholesterol과 지질대 사에 미치는 영향 윤현숙
  3. 가정의학회지 v.15 no.8 연령에 따라 과체중이 혈중지질치에 미치는 영향 이석기
  4. 순환기 v.21 no.2 고콜레스테롤 혈증에 대한 LOVASTATIN의 효과 이수영;경춘숙;김동찬;이계획;최상전;손인;박성훈
  5. 사망원인별 통계년보 v.14 통계청
  6. 한국체육학회지 v.34 no.2 수영이 임신한 흰쥐의 생리학적 변화에 미치는 영향 한성수
  7. Int. J. Sports. Med. v.14 no.7 Effects of Aerobic and An aerobic Tranining of Plasma Lipoproteins Aellen, R.;Hollmann, W.;Boutellier, U.
  8. Am. J. Clin. Nutr. v.39 Downregulation of the low density lipoprotein receptor by dietary cholesterol Applebaum-Boden, C.;Haffer SM;Hartsook E.;Luk Kh;Albers JJ.;Hazzard WR
  9. Circ. Res. v.27 Regression of Coronary Atherosclerosis in Rhesus Monkeys Armstrong, M.L.;Warner, E.D.;Connor, W.E.
  10. J. Appl. Physiol.: Resprorat. Environ. Exercise Physiol. v.47 no.6 Mazimum Oxygen Consumption of Rats and Its Changes with Various Experimental Procedures Bedford, T.G.;Tipton, C.M.;Wilson, N.C.;Oppliger, R.A.;Gisolfi, C.V.
  11. Sports Med. v.17 no.1 Physical Activity and Lipoprotein Ligid disorders Berg, A.;Frey, I.;Baumstark, M.W.;Halle, M.;Keul, J.
  12. Am. J. Pathol. v.101 Myocardial Infartion in a Large Colony of Nonhuman Primates withe Coromary Artery Atherosclerosis Bond, M.G.;Bullock, B.C.;Bellinger, D.A.;Hamm, T.E.
  13. Arterioscler. thromb. v.11 no.4 Effect of exercise tranining on cardiovascular function and plasma lipid, lipoprotein, and apolipoprotein concentrations in premenopausal and postmenopausal women Brummental, J.A.;Matthews, K.;Fredrikson, M.;Rifai, N.;Schniebolk, S.;German, D.;Steege, J.;Rodin, J.
  14. Med. Sci. Sports Exerc. v.16 no.3 Effect of High and Low Intensity Exercise Traning of Aerobic Capacity and Blood Lipid Caesser, G.A.;Rich, R.G.
  15. J. Biol. Chem. v.257 Chao, Y.S.;T.T. Yamin;A.W. Alberts
  16. JAMA v.236 Physical Fitness Levels vs. Selected Conorary Risk Factors Cooper, K.H.;Pollock, M.L.;Martin, R.P.;White, S.;Linnerud, A.;Jackson, A.
  17. Am. J. Cardiol. v.42 Relation of Lipid, Weight and Physical Activity to Incidence of Coronary Heart Disease Costar, R.;Carcia-Palmieri, M.R.;Nazario, E.;Sorlie, P.D.
  18. J. Am. Med. Assoc. v.243 Plasma catecholamine in stress and exercise Dimsdale, J.E.;Moss, J.
  19. Univ. Arizona Degress:PHD Association of Regional and Total Body Composition, Plasma Lipids, Lipoproteins, Apolipoprotein and the Effects of Long Term Resistive Training in the Premenopausal Female Ensign, W.Y.
  20. Rev. Esp. Fisiol. v.47 no.4 High Density Lipoprotein Subfractions and Physical Activity : Changs after moderate and Heavy Exercise Training Fernandez, P.J.;Rubies, P.J.;Pedro, B.J.(et al.)
  21. J. Sprots. Med. Phys. Fitness. v.31 no.2 Specialized Physical Training Programs: Effects on Serum Lipoprotein Cholesterol, Apoproteins A-I and B and Lipolytic Enzyme Activities Giada, F.;Blada, E.G.;Baiocchi, M.R.;Zuliani, G.;Vitale, E.;Fellin, R.
  22. Am. J. Med. v.62 Girdib, T.;W,P. Casteli.;M.C. Hjortland;W.B. Kannel;T.R. Dawber
  23. Prev. Med. v.13 no.1 Exer Induced Changes in Plasma Lipids and Lipoprotein Heskell, W.
  24. Arterioscler. Thromb. v.14 no.3 Human Performance Laboratory Houmard, J.A.;Bruno, N.J.;Bruner, R.K.;McCammon, M.R.;Israel, R.G.;Barakat, H.A.
  25. Univ. Tech. Loughborough (United Kingdom) Degree : PHD Low Intensity Exercise, Functional Capacity and Lipoprotein Metabolism in Women (Walking 0 Hudson, A.
  26. Univ. East Texas Degree: EDD Effects of Aerobic Walking and Nutrition on Blood Lipids, Body Composition, Weight, and Cardio-vascular Fitness Jones, C.A.
  27. Ann. Intern. Med. v.74 Serum Cholesterol, Liporotein and Risk of Coronary Hear Dsease.;The Framingham Stydy Kannel, W.B.;Castelli, W.P.;Gordon, T.;Mcnamara, P.M.
  28. Nippon Koshu Eisei Zasshi. v.41 no.1 Effect of Traning Fitness on Obesity, Hypertension, Hyperlipidemiaanda Disorders in Glucose Metabolism Katoh, M.;Hashimoto, S.;Ohta, T.;Okada, K.(et al.)
  29. Circulation v.41 Heart Desease in Seven Countries Keys, A.
  30. Federation Proc. v.38 no.6 Diet, lipod metabolism and aging Kirthcevsky, D.
  31. JAMA v.251 The Lipid Research Clinics Coromary Primary Prevention Trial results: Ⅰ. Reduction in incidence of coromary heart disease
  32. Atherosclerosis. v.31 Treatment established atherosclerosis during cholesterol feeding in monkeys Malinow, M.R.;McLaughlin, P.;McNulty, W.P.
  33. Exp. Mol. Path ol. v.17 Development, Distribution and Lipid Content of Dietuinduced Atherosclerotic Leisons of Rhesus Monkeys manning, P.J.;Clarkson, T.B.
  34. Atherosclerosis. v.87 no.1 Lifestyle Determinates of HDL₂ and HDL3-Cholesterol Levels in a Hypercholesterolemic Male Population Manttari, M.;Koskinen, P.;Manninen, V.;Tenkanen, L.;Huttunen, J.K.
  35. Amm. Rev. Public Health v.8 Physical Antivity and the Incidenec of Coronary Heart Desease Powell, F.(et al.)
  36. Biochem. Biophys. Res. Commun. v.167 14,15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U973 cells Pritchard, K.A.;Tota, R.R.;Stemerman, M.B.;Wong, Py-K.
  37. N. Engl. J. med. v.295 The Pathogenesis of Atherosclerosis Ross, R.;Glomset, J.A.
  38. J. Lipid. Res. v.20 Study of the Atherogenic Dyslipoproteinemia Induced by Dietery Cholesterol in Rhesus Monkeys Rudel, L.L.;Shah, R.;Greene, D.G.
  39. Athero-sclerosis Rev. v.3 Arterial Endothelial Structure and Funtion withe Particular Reference to Permeability Schwartz, C.J.;Gerrity, R.G.;Lewise, L.J.
  40. J. Biol. Chem. v.255 Slater, H.R.;C.J. Packard;S. Bicker;J. Shepherd
  41. Population studies. "Nutrition, Lipid and Coronary Heart Disease" Stamler, J.
  42. Prog cardiovascular disease v.30 The relationship of hypercholesterolemia to atherosclerosis with particular emphasis on familial hyperchole-sterolemia, DM, obstructive jaundice Stehben, W.Z.;Wierzbicki, E.
  43. Chung hua Liu Hsing Ping Hsueh Tsa Chih. v.12 no.4 Study of Expercise and Serum Lipids in Pyberty Sun, Y.
  44. Circulation v.76 Review of lipid lowering clinical trials in relation to obsevational epidemiological studies Tylroler, H.A.
  45. Lipids v.14 The effects of Exercise on Plasma High Density Lipoproteins Wood, P.;Haskel, W.
  46. Res. Q. Exerc. Sprots. v.64 no.3 The Importance of Physical Fitness vs. Physical Activity for Coronary Artery Desease Risk Factors: A Cross-sectional analysis Young, D.R.;Steinhardt, M.A.
  47. 運動生理生化學 山田 茂;見 順子;富野 士良;原田 邦彦;岩垣 丞恒;堤 達也;平田耕造