Acute Esophageal Stricture After Induction Chemotherapy for Acute Leukemi - Report of a case -

급성 백혈병의 유도 화학요법후에 발생한 급성 식도협착

  • Yoon, Hoo-Sik (Department of Thoracic and Cardiovascular Surgery, Maryknoll Hospital) ;
  • Chang, Ki-Kyung (Department of Thoracic and Cardiovascular Surgery, Maryknoll Hospital) ;
  • Kang, Jeong-Soo (Department of Thoracic and Cardiovascular Surgery, Maryknoll Hospital) ;
  • Kim, Hun (Department of Thoracic and Cardiovascular Surgery, Maryknoll Hospital) ;
  • Kim, Ho-Kyun (Department of Internal Medicine, Maryknoll Hospital) ;
  • Kim, Byung-Chang (Department of Clinical Pathology, Maryknoll Hospital) ;
  • Chun, Bong-Kwon (Department of Anatomic Pathology, Maryknoll Hospital)
  • 윤후식 (메리놀병원 흉부외과) ;
  • 장기경 (메리놀병원 흉부외과) ;
  • 강정수 (메리놀병원 흉부외과) ;
  • 김훈 (메리놀병원 흉부외과) ;
  • 김호균 (메리놀 병원 내과) ;
  • 김병창 (메리놀 병원 임상병리과) ;
  • 천봉권 (메리놀 병원 해부병리과)
  • Published : 1998.05.01

Abstract

Although dysphagia in patients with acute leukemia is usually related to reflux esophagitis, infectious esophagitis, chemotherapy1) and leukemic infiltration2), acute esophageal stricture resulting from chemotherapy in the patient with leukemia is very rare. A 40-year-old man with acute myelogenous leukemia was admitted for operation of esophageal stricture which was developed within 1 month of chemotherapy. An esophagectomy and esophagogastrostomy with pyloroplasty was carried out. Histology showed mucosal infiltration of mononuclear cells and transmural fibrosis involving submucosa and the muscle layer.

氷복茸兌\ulcorner환자에서 발생하는 연하곤란은 보통 역류성 식도염, 감염성 식도염, 화학요법 및 백혈병의 직접적인 식도 침범에 의해 발생하지만 그중에서도 백혈병 환자의 화학요법의 결과로 발생하는 식도협착중 급성으로 발병하는 경우는 아주 드물다. 본원에서는 40세의 남자환자가 급성 골수성 백혈병으로 화학요법 받은지 1개월 이내에 발생한 급성 식도협착으로 수술위해 입원, 식도 절제술 및 위식도 문합술 과 유문부 성형술을 시행하였다. 병리 조직검사상 단핵구들의 점막 침착 및 점막하조직과 근육층을 침범하는 섬유화소견을 보이고 있다.

Keywords

References

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  2. Cancer v.71 Leukemic infiltration of the esophagus Fulp SR;Nestok BR;Powell BL;Evans JK;Geisinger KR;Gilliam JH III
  3. Pediatr Hematol Oncol v.10 Post-monilial extensive esophageal stricture (letter) Ismail A;Abdulla S
  4. Ann Intern Med v.85 Adriamycin and enhanced radiation reaction in normal esophagus and skin Greco FA;Brereton HD;Kent H;Zimbler H;Merrill J;Johnson RE