Archives of Pharmacal Research
- Volume 21 Issue 3
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- Pages.353-356
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Boron Trifluoride Etherate on Silica-A Modified Lewis Acid Reagent (VII). Antitumor Activity of Cannabigerol Against Human Oral Epitheloid Carcinoma Cells
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Baek, Seung-Hwa
(Department of Chemistry, Wonkwang University)
;
- Kim, Young-Ok (Department of Chemistry, Wonkwang University) ;
- Kwag, Jung-Suk (Department of Dental Hygenic, Mokpo Junior College) ;
- Choi, Kyw-Eun (Department of Chemistry, Wonkwang University) ;
- Jung, Woo-Young (Department of Oral Anatomy, Wonkwang University) ;
- Han, Du-Seok (Department of Oral Anatomy, Wonkwang University)
- Published : 1998.06.01
Abstract
Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibrobalsts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.
Keywords
- Cannabinoid;
- 5-Fluorouracil;
- Cannabigerol;
- Antitumor activity;
- Human oral epitheloid carcinoma cell;
- MTT assay;
- SRB assay