Prolyl Endopeptidase Inhibitors from Caryophylli Flos

  • Lee, Kyung-Hee (Department of Agricultural Chemistry, College of Agriculture, Kyungpook National University) ;
  • Kwak, Jong-Hwan (College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Kyung-Bok (Department of Chemistry, KonYang University) ;
  • Song, Kyung-Sik (Department of Chemistry, KonYang University)
  • 발행 : 1998.04.01

초록

Three prolyl endopeptidase inhibitors were isolated and identified as luteolin, quercetin and ${\beta}$-sitosterol-3-O-${\beta}$-D-glucopyranoside with $IC_{50}$ of 0.17, 0.19 and 27.5 ppm, respectively. The inhibition of two flavonoids were non-competitive with substrate. Twenty authentic flavonoids were tested in order to investigate structure-activity relationship. No significant relationship was found in them, however, catechol moiety of B-ring and 7-OH group in flavonoid skeleton were seemed to be responsible for the stronger activity.

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