Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Epoxyalkanoyls as Novel ACE Inhibitors

  • P. Choo, Hea-Young (School of Pharmacy, Ewha Womans University) ;
  • Yoon, Hea-Ran (School of Pharmacy, Ewha Womans University) ;
  • Park, Hwha-Soon (School of Pharmacy, Ewha Womans University) ;
  • Kim, Dong-Hyun (Doping Control Center, Korea Institute of Science and Technology) ;
  • Park, Jong-Sei (Doping Control Center, Korea Institute of Science and Technology) ;
  • Kim, Dong-H. (Department of Chemistry, Pohang University of Science and Technology)
  • Published : 1998.04.01
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Abstract

The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was $IC_{50}$ values of 0.06~5.5 ${\mu}M$.

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