Archives of Pharmacal Research
- Volume 21 Issue 2
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- Pages.157-163
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
- Choi, Bo-Gil (College of Pharmacy, Chonnam National University) ;
- Kim, Ok-Young (College of Pharmacy, Chonnam National University) ;
- Chung, Byung-Ho (College of Pharmacy, Chonnam National University) ;
- Cho, Won-Jea (College of Pharmacy, Chonnam National University) ;
- Cheon, Seung-Hoon (College of Pharmacy, Chonnam National University) ;
- Choi, Sang-Un (College of Pharmacy, Chonnam National University) ;
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Lee, Chong-Ock
(Korea Research Institute of Chemical Technology)
- Published : 1998.04.01
Abstract
Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.