Archives of Pharmacal Research
- 제21권1호
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- Pages.73-75
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and In vitro Evaluation of 4-Substituted-1-azaanthraquinones
- Lee, Hee-Soon (College of Pharmacy, Chungbuk National University) ;
- Hong, Seoung-Soo (College of Pharmacy, Chungbuk National University) ;
- Choi, Jae-Young (College of Pharmacy, Chungbuk National University) ;
- Cho, Jung-Sook (College of Medicine Dong-guk University) ;
- Kim, Young-Ho (College of Pharmacy, Chungnam National University)
- 발행 : 1998.02.01
초록
In summary, six 4-substituted-1-azzanthraquinones were designed and synthesized using hetero Diels-Alder reaction as a key step. Although a great number of reaction conditions for benzylic bromination were examined, this step need to be improved for the efficient synthesis of the related analogues. 4-Bromomethyl-1-azzanthraquinone 6 may have potential for the treatment of tumors resistant to the doxorubicin. The compounds 9 and 10 containing the latent alkylating functionality may need further in depth biological evaluation. Work is in progress to design, synthesize, and evaluate additional compounds in this and related systems.
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