Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Isolation and Identification of Inhibitory Compounds on TNF-$\alpha$ Production from Magnolia fargesii

  • Chae, Sook-Hee (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Kim, Pyoung-Su (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Cho, Jae-Youl (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Park, Ji-Soo (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Lee, Jae-Ho (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Yoo, Eun-Sook (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Baik, Kyong-Up (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Lee, Jong-Soo (Research and Development Center, Daewoong Pharmaceutical Co.) ;
  • Park, Myung-Hwan (Research and Development Center, Daewoong Pharmaceutical Co.)
  • Published : 1998.02.01
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Abstract

Three TNF-$\alpha$inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-$\alpha$ production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity ($IC_{50}=51{\mu}M)$.

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