Synthesis and Pharmacokinetic Profile of 3-Methoxymethyl Cephalosporin Prodrugs

Jung, Myung-Hee;Cho, Kui-Woong;Park, Jewn-Giew;Kim, Young-Hee;

Archives of Pharmacal Research

Volume 21 Issue 5
/
Pages.559-564
/
1998
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0253-6269(pISSN)
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1976-3786(eISSN)

The Pharmaceutical Society of Korea (대한약학회)

Synthesis and Pharmacokinetic Profile of 3-Methoxymethyl Cephalosporin Prodrugs

Jung, Myung-Hee (Korea Research iNstitute of Chemical Technology) ;
Cho, Kui-Woong (Korea Research Institute of Chemical Technology) ;
Park, Jewn-Giew (Korea Research institute of Chemical Technology) ;
Kim, Young-Hee (Korea Research Institute of Chemical Technology)

Published : 1998.10.01

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Abstract

Preparation and biological activity of prodrug-type 3-methoxymethyl cephalosporins were described. From the mixtures, R- and S-prodrugs were separated and their absolute configurations were determined, and also their bioavailability was investigated.

Keywords

References

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