한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제8권1호
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- Pages.23-28
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- 1998
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
아테놀올의 체내동태에 대한 신장해의 영향
Effect of Renal Failure on Pharmacokinetics of Atenolol in Rabbits
- Lee, Chong Ki (Kwangju City Health and Environment Research Institute) ;
- Cho, Sam Sang (Kwangju City Health and Environment Research Institute)
- 발행 : 1998.05.01
초록
The pharmacokinetics of atenolol (25 mg/kg, i.v.) in the folate-induced renal failure rabbits was studied. Renal failure was induced by the i.v. injection of folate (50, 100, and 200 mg/kg). At folate dose of 100 and 200 mg/kg, the serum creatinine concentration (Scr) and blood urea nitrogen (BUN) increased significantly compared with control rabbits. Plasma concentrations and AUC of atenolol increased significantly at folate dose of 100 and 200 mg/kg. The elimination rate constant