The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
권호 표지

Effects of Cheonggisan and Gagamcheonggisan on the anti-allegic and immune responses in mice

청기산(淸肌散)과 가미청기산(加味淸肌散)이 마우스의 항(抗)알레르기 및 면역반응(免疫反應)에 미치는 영향(影響)

  • Park Eun-Jeong (Dept. of Pediatrics, College of Oriental Medicine, Won Kwang University) ;
  • Kim Yang-Gwi (Dept. of Pediatrics, College of Oriental Medicine, Won Kwang University)
  • 박은정 (원광대학교 한의과대학) ;
  • 김양귀 (원광대학교 대학원 한의학과 소아과)
  • Published : 1998.12.15
Download PDF
⟨ Previous Next ⟩

Abstract

Cheonggisan(CGS) is well known for its effect on such allergic disease as urticaria and atopic dermatitis. Gagamcheonggisan(GCGS) was formulated by subtracting several herbs from CGS and adding several herbs to CGS. Even though it is being used frequently in the clinicai medicine for the treatment of above hypersensitivity diseases, basic study to make sure the mechanism of its action is rare. In this study the author tried to know the effect of CGS and GCGS on the vascular permeability, contact dermatitis, granular secretion from mast cells and function of macrophages. The results obtained in this study are as follows : 1. Administration of CGS and GCGS decreased the vascular permeability induced by serotonin and histamine. The decrease by serotonin is more typical and dose-dependent. 2. Administration of CGS and GCGS inhibited foot-pad and ear swelling responses induced by sheep red blood cells and picryl chloride respectively, the inhibition of foot-pad swelling responses is bigger than that of ear swelling responses and both of them are not dependent on the dose3. Treatment of peritoneal mast cells with CGS and GCGS water extract decreased the histamine release triggered by compound 48／80 in a dose dependent fashion 4. Administration of CGS and GCGS increased the phagocvtic activity of peritoneal macrophages and treatment of peritoneal macrophages with CGS activated phagocytic function in a dose dependent fashion. 5. Administration of CGS and GCGS enhanced such reactive oxygen intermediates(ROIs) as superoxide and hydrogen peroxide production from peritoneal macrophages. 6. Treatment of CGS and GCGS activated peritoneal macrophages for the production of ROIs. The above results show that CGS and GCGS decreased the hypersensitivity reactions by inhibiting non-specific inflammatory mediator release and vascular permeability without affecting general immune responsiveness.

Keywords

References

  1. 東醫寶鑑 許俊
  2. 醫學入門 李정
  3. 臨證醫案醫方 孫一民
  4. 萬病萬藥 金海秀
  5. 諸病源候論 巢元方
  6. 黃帝內經素問今釋 王琦(外)
  7. 睛岡醫鑑 金永勳
  8. 診療要鑑 金定濟
  9. 韓方外科 蔡炳允
  10. 丹溪心法附餘 方廣
  11. 皮膚科學 姜炯齊
  12. 瘍醫大全 顧世澄
  13. 百病辯證錄 陳士鐸
  14. 臨床各科疾病療法 顧伯華
  15. 最新韓方臨床學 裵元植
  16. 中醫外科學 上海中醫學院
  17. 醫宗金鑑 吳謙(外)
  18. 聖濟總錄 趙佶
  19. 濟衆新編 康命吉
  20. 東醫臨床要覽 金定濟;金賢濟
  21. 靑囊決 南采祐
  22. 方藥合篇解說 申載鏞
  23. 神珍經驗神方 李麟宰
  24. 方藥合篇 黃度淵
  25. 醫宗損益 黃度淵
  26. 醫門寶鑑 周命新
  27. 傷寒類證活人書 朱肱
  28. 家庭醫學 醫學敎育硏修院
  29. 原色最新醫療大百科辭典 李榮基
  30. 月刊臨床藥學 金榮湖
  31. 最新免疫學 李淵台
  32. 免疫學 김세종
  33. 幼科金鍼 泰景明
  34. 洪家定診秘傳 洪淳昇
  35. 中醫臨床手冊 原安徵中醫學院(編)
  36. 六科準繩 v.5 王肯堂
  37. 徐靈台書全集 徐靈台
  38. 常見病證辨證疹治療槪要 白洪光
  39. 中醫症狀鑑別診斷學 中醫硏究院
  40. 增補韓方臨床四十年 朴炳昆
  41. 秘急千金要方 孫思邈
  42. 三因極一病證方論 陳言
  43. 奇效良方 方賢
  44. 中醫外科學 顧伯康
  45. 小兒科學 홍창의(編)
  46. 東醫小兒科學 丁奎萬
  47. 中醫兒科學 上海中醫學院
  48. 中醫外科護理 孫世道(外 3人)
  49. 普濟方 朱숙
  50. 珍本醫書集成, 十一冊 六因條辨 陸子賢
  51. 萬病回春 v.3 공廷賢
  52. 太平聖蕙方 v.24;91 王懷隱
  53. 聖濟總錄 正和泰勅
  54. 古今醫統秘方大全 徐春甫
  55. 中醫臨床大系 北京中醫學院
  56. 알레르기와 韓方 丁奎萬
  57. 韓方臨床알레르기 康乘秀
  58. 면역학 서울대학교의과대학
  59. 方制學 李商仁
  60. 本草學 李尙仁
  61. 韓藥臨床應用 李尙仁(外)
  62. 漢方醫藥大辭典 v.I;II;III;IV 陳存仁
  63. 原色臨床本草學 辛民敎
  64. 大韓韓醫學會誌 v.11 no.2 小兒隱疹에 관한 文獻的 考察 朴恩貞
  65. 大韓韓醫學會誌 v.14 no.1 隱疹(蕁麻疹)에 관한 文獻的 考察 李廷淑
  66. 大韓韓醫學會誌 은疹患者에 대한 臨床的 考察 金中鎬(外)
  67. 防風通聖散 및 防風通聖散加味方이 抗알레르기와 免疫反應에 미치는 影響 李東弦
  68. 大韓外官科學會誌 v.4 no.1 消風散과 加味消風散이 免疫反應 및 抗알레르기에 미치는 影響 金中鎬(外)
  69. 慶熙大學校論文集(13) 仙方敗毒湯이 抗알레르기 作用에 미치는 影響 李在媛(外)
  70. 大韓外官科學會誌 v.8 no.1 升麻葛根湯加味方이 마우스의 抗알레르기 및 免疫反應에 미치는 影響 金南權
  71. 淸肌散의 效能에 관한 實驗的 硏究 金惠靜
  72. 大韓小兒科學會誌 v.21 알레르기의 免疫學的 背景 강석영
  73. 韓方治療劑의 標準化規格 統一硏究 李尙仁(外)
  74. 大韓皮膚科學會誌 v.31 no.3 알레르기성 접촉피부염과 원발성 접촉피부염에서 랑게르한수세포, la양성 각질형성세포와 Thy-1양성 수지상표 피세포의 변화 조남준(외)
  75. A Kinetic Study of Antibody Producing Cells in the Spleen of Mice Immunized Intravenously with sheep erythrocutes v.14 Biozzi, G.;Stiffel, C.;Mounton, D.;Bouthiler, Y.;Decrusefound, C.
  76. J. Nat. Cancer Inst. v.51 Immunopotentiation with BCGII, modulaton. of the response to sheep red blood cells Miller, T.E.(et al.)
  77. Immunology v.34 Delayed hypersensitivity in mice induced by intravenous sensitzation with sheep erythrocytes : evidence fortuberculin type delayed hypersencitivity of the reaction Mitsuoka, A.(et al.)
  78. Microbiol. Immunology. v.22 Katayama, S.;Shionaya, H.;Ohtake, S.
  79. Folia phamachol., Japan v.80 Anti-allergic action of drugs and blended chiese traditional medicines : Effect on Type I and Type IV allergic reaction Koda, A.(et al.)
  80. 日藥理誌 v.80 Oxatominde 약리작용 大森健守(외)
  81. Immunology v.15 Asherson, G.L.;Ptak.
  82. J. Biol. Chem. v.252 Native hepar in from rat peritoneal mast cell Yurt R.W.;Leid, R.W.;Austen, K.F.
  83. J. Pharmacol. Exp. Ther. v.127 A method for fluorometric assay of histamine in tissues Shore, P.A.;Burkhalter, A.;Cohn, V.H.
  84. Macrophages associated with epithelia Anant. Rec. v.210 The monouclear phagocyte system of the mouse defimed by immuno- histochemical localization of antigen F 4/80 Hume, D.A.;Loutit, J.F.;Gordon, S.
  85. J. Cell. Sdi. v.66 The mononuclear phagocyte system of the mouse defimed by immunohisto- chemical localization of antigen F4/70. Macrophages of bone and associated connective tissue Hume, D.A.;Loutit, J.F.;Gordon, S.
  86. J. Res. v.32 Characterization of the mnnose fucosyl receptor on human monouclear phagocytes Shepherd, V.L.;Comphell, E.J.;Sienior, R.M.;Stahl, P.D.
  87. J. Cell. Biol. Yeast mannose inhibits binding and phagocytosis of zymosan by mouse peritoneal macrophages Suny, S.S.J.;Nelson, R.S.;Silverstein, S.C.
  88. Cell. Immunol. v.79 Persistent expression of IgA-antigen on a subpopulation of murine resident peritoneal macrophages Walker, W.S.;Hester, R.B.;Beelen, R.H.J.
  89. 中西醫結合雜誌 v.5 no.3 介紹一種豊材常見皮膚病一丘疹樣蕁麻疹 劉世明
  90. J. Vet. Med. v.834 Measuring phagocytic capacity in polymorphonuclear cell of the pig a comparison between different assay Winter, M.;Buschmann, H.G.
  91. Nature v.268 Dissociation of effector function in populations of activated macrophages Winy, E.J.;Gardner, I.D.;Ryminy, F.W.;Reminyton, J.S.
  92. J Immunol v.118 Enhancement Of carriemediated transport after immunological activation of peritoneal macrophage Bonventre, P.F.;Strauss, D.;Baughn, R.E.;Imhoff, J.
  93. J Biochem v.234 The biochemical basis of phagocytoisis Sbarra, A.J.;Kaenovsky, M.L.
  94. Eur, Immunol. v.141 Interferon-T and tumor-necrosis factor the L-arginine-depedent cycotoxic effector mechanism in murine macrophages Drapier, J.C.;Wietzerbin, J.B.;Hibbs
  95. Cell, Immunol. v.101 Modification of the murine immune system by glucocorticosteroids of circulation lymphocytes Cheung, H.T.;Samlowski, W.E.;Daynes, R.A.
  96. antibody formation at the cellular level in immunology Abrames, L.;Bach, J.F.;Preud homme, J.L.
  97. Cellular Immunology. v.3 Antigen recognition by T lymphocytes Bach, J.F.;Dardenne, M.
  98. J.Immunol. v.140 The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4 helper(+), CD8 suppressor T cells and restricted to the DR region of the MHC Complex Schmid, D.S.
  99. Int. Arch. Allergy Apple. Immunol. v.86 Natural cytotoxicity in adult acute leukemia Soerskaar, D.;Foerre, Oe.;Albrechtsen, D.;Slavem, P.
  100. The failure if thymus-derived cells to produce antibody Transplantation v.5 Davis, A.J.S.(et al.)
  101. Eur. J. Immunol. F4/80 : monoclonal antibody directed specifically against the mous macrophage Austyn, J.M.;Gorden, S.