대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제12권1호
  • /
  • Pages.163-181
  • /
  • 1998
  • /
  • 1226-8038(pISSN)
  • /
  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
권호 표지

강활(羌活)이 가토(家兎) 혈관평골근(家兎 血管平滑筋)의 긴장성(緊張性) 조절(調節)에 미치는 영향(影響)

The Effects of Notopterygii Rhizoma on the Carotid Arterial Tension in Rabbit

  • 장규태 (동국대학교 한의학대학 소아과) ;
  • 김장현 (동국대학교 한의과대학)
  • 발행 : 1998.12.15
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초록

The purpose of this study was to analyze the Rhizoma on the blood pressure, heart rate and to define the mechanism of Notopterygii Rhizoma-induced relaxation in rabbit common carotid arterial contracted by agonists. Method : In order to explore the effect of Notopterygii Rhizoma on the blood pressure and heart rate, Notopterygii Rhizoma extract was injected in vein of rabbit ear. In order to investigate the effect of Notopterygii Rhizoma on norepinephrine(NE)-induced contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Notopterygii Rhizoma-induced relaxation, Notopterygii Rhizoma extract infused into NE-induced contracted strips induced by agonists after treatment of methylene blue, propranolol, ouabain and it infused into serotonin, potassium chloride-induced contracted strips. Result : The blood pressure was significantly decreased by Notopterygii Rhizoma, but heart rate was insignificantly. In addition, Notopterygii Rhizoma significantly relaxed the norepinephrine, serotonin, potassium-induced contracted strips with intact endothelium or damaged endothelium. The relaxing effect of Notopterygii Rhizoma In NE-induced contracted strips with damaged endothelium by pretreatment of methylene blue, propranolol was not changed, but Ouabain was significantly decreased. Conclusion : These results were shown that Notopterygii Rhizoma affected the NE -induced contracted smooth muscle without the participation of endothelium, and demonstrated that the mechanism of NotoDtervgii Rhizoma-induced relaxation was the obstruction of receptor-operated Ca2+ channel.

키워드

참고문헌

  1. 生理學 v.8 姜斗熙
  2. 本草學 康秉秀(등)
  3. 臟腑辨證論治 金完熙;崔達永
  4. 생명의 이치 血液${\cdot}$心臟${\cdot}$循環 金祐謙
  5. 診療要鑑(下) 金定濟
  6. 심장학 서울대학교 의과대학
  7. 그림으로 보는 생리학 신문규;이한기
  8. 東醫診療大全 安載福
  9. 漢藥臨床應用 李尙仁(등)
  10. 약리학강의 이우주;홍사석
  11. 精校黃帝內經素問 洪元植
  12. Propranolol 전처리 가토에서 Theophyline 동태학적 연구 고숙영
  13. 大韓韓醫學會誌 v.3 no.2 高血壓治療의 辨證에 關한 硏究 金完熙
  14. 폐렴이 家兎의 血管內皮細胞性 弛緩因子에 미치는 影響 金昊顯
  15. 東醫生理學會誌 v.11 no.2 龍膽瀉肝湯이 家兎 血管平滑筋의 緊張性調節에 미치는 影響 孟仙淑;申興默;金吉萱
  16. 내피세포 의존성 혈관이완에 대한 Na+-K+ pump의 영향 박태식
  17. 동국의학 v.2 세포외 Ca2+와 Ca 길항제들이 내피세포성 이완인자의 분비에 미치는 영향 서석효
  18. Co2+과 저분극 유발인자들이 내피세포의존성 과분극과 내피세포성 이완인자의 분비 및 작용에 미치는 영향 서석효
  19. 羌活水鍼이 鎭痛 및 血淸 Cholinesterase 活性에 미치는 影響 申相習
  20. 羌活성분이 mouse자발운동에 미치는 영향 신현식;김학성(등)
  21. 韓國産 羌活의 品質評價方法에 관한 硏究 尹永錫
  22. Serotonin에 의한 가토신동맥 평활근 수축기전 이우영
  23. Journal of the pharmaceutical Society of Korea v.14 한국산 산형식물의 성분연구(IX), Isoimperatorin 및 Oxypeucedanin의 일반약리작용 지형준;김학성
  24. 大韓韓醫學會誌 v.11 no.2 風의 生理學的 認識 黃寅秀
  25. 臟象槪說 盛增秀;王琦
  26. 黃帝內經素問譯解 楊維傑
  27. 醫學正傳 虞搏
  28. 本草從新 吳儀洛
  29. 黃帝內經素問集注 張隱庵
  30. 高血壓 趙光勝
  31. 百家配伍用藥經驗采薺 肖森茂;彭永開
  32. 現代中醫內科學 何紹奇
  33. J. Physiol. v.351 Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea-pig anterior mesenteric artery Bolton, T.B.;Lang, R.J.;Takewaki, T.
  34. Arch, Pharm. Res. v.14 no.1 Pharmacological Activities of Water Extracts of Umbelliferae Plants Kim, C.M.;Heo, M.Y.;Kim, H.P.;Sin, K.S.;Pachaly, P.
  35. Br. J. Pharmacol. v.93 no.3 Endothelium-dependent hyperpolarization of canine coronary smooth muscle Feletou, M.;Vanhoutte, P.M.
  36. The pharmacological basis of therapeutics Gilman, A.G.;Goodman, L.S.;Rall, T.W.;Murad, F.
  37. Arterial Hypertension v.5 Gross, F.;Robertson, J.I.S.
  38. Medical Physiology v.20 Guyton, A.C.
  39. Angiology v.11 Serotonin and vascular system Haddy, F.J.
  40. Circ. Res. v.65 no.1 Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein Ignarro, L.J.
  41. Pharmacology and Experimental Therapeutics v.237 Activation of purified solublegyanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein : stimulation Ignarro, L.J.;Harbison, R.G.;Wood, K.S.;Kadowitz, P.J.
  42. Acta. Anaesthesiol. Scand. v.37 no.99 Therapies for perioperative hypertension ; Pharmacodyn-amic considerations Levi, R.
  43. Nature v.327 Nitric oxiderelease accounts for the biological activity of endothelium-derived relaxing factor Palmer, R.M.J.;Ferrige, A.G.;Moncada, S.
  44. Pharmacologia Clinica v.2 The pharmacodynamics and metabolism of propranolol in man Paterson, J.W.;Conolly, M.E.;Hayes, A.;Cooper, R.G.
  45. Am. J. Physiol. v.263 EDRF plays central role in collateral flow after arterial occlusion in rabbit ear Randall, M.D.;Griffith, T.M.
  46. Circ. Res. v.52 no.3 Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP Rapoport, R.M.;Murad, F.
  47. J. Physiol. v.264 Nitroarginine-sensitive and -insensitive components of the endothelium-dependent relaxation in the guinea-pig carotid Suzuki, H.;Chen, G.;Yamamoto, Y.;Miwa, K.
  48. Circulation v.72 no.4 Platelets, endothlium, and vasospasm Vanhoutte, P.M.;Houston, D.S.
  49. Ann. Rev. Physiol. v.48 Modulation of vascular smooth muscle contraction by the endothelium Vanhoutte, P.M.;Rubanyi, G.M.;Miller, V.M.;Houton, D.S.
  50. Biochemistry Voet, D.;Voet, J.G.
  51. Br. J. Pharmacol. v.108 no.3 The effect of NG-nitro-L-argininemethyl ester upon basal blood flow and endothelium-dependent vasdilatation in the dog hindlimb White, D.G.;Drew, G.M.;Gurden, J.M.;Penny, D.M.;Roach, A.G.;Watts, I.S.