The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Protective effects of extract of Brousson etiae fructus on the nitrite level and the nitric oxide synthase activity in corpus cavernosum of streptozotocin-induced diabetic rat.

저실자(楮實子) 추출물(抽出物)이 Streptozotocin에 의한 당뇨병(糖尿病) 흰쥐 음경해선체(陰莖海綿體)의 Nitric oxide synthase 활성(活性) 및 Nitrite 함량(含量)에 미치는 영향(影響)

  • Kang, Jeong-Jun (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Shin, Uk-Seob (Dept. of Pharmacy, Dongguk Medical Center)
  • 강정준 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 신억섭 (동국대학교 의료원 약제과)
  • Published : 1998.10.30
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Abstract

The purpose of this study was to investigate the effect of Brousson etiae fructus (BF) on the urethral nitrite level and the urethral nitric oxide synthase (NOS) activity in streptozotocin (STZ) induced diabetic rats. In vitro, the urethral NOS activity was not noted in the level of Dose of extract prepared from BF. In vivo, the urethral NOS activity was increased in normal rats and STZ induced diabetic rats by dose and term of extract prerared from BF. The the NOS activity decreased in STZ induced diabetic rats was increased as highly as norma1 group by the extract of BF The level of urethral nitrite and glutathione was increased too. But the level of urethral lipid peroxide increased in STZ induced diabetic rats was decreased as lowly as normal group by the extract of BF. In conclusion, the extract of BF can restore erectile dysfunction of STZ induced diabetic rats.

Keywords

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