The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Effects of Gentiana marcrophylla on Immune Response in the Collagen induced Arthritis

진구가 Collagen유발(誘發) 관절염(關節炎)의 면역반응(免疫反應)에 미치는 영향(影響)

  • Kim, Seong-Jae (Dept. of Interanl Medicine, College of Oriental Medicine, WonKwang University) ;
  • Lee, Eon-Jeong (Dept. of Interanl Medicine, College of Oriental Medicine, WonKwang University) ;
  • Kim, Hyeong-Kyun (Dept. of Interanl Medicine, College of Oriental Medicine, WonKwang University) ;
  • Song, Bong-Keun (Dept. of Interanl Medicine, College of Oriental Medicine, WonKwang University)
  • 김성재 (원광대학교 한의과대학 내과학교실) ;
  • 이언정 (원광대학교 한의과대학 내과학교실) ;
  • 김형균 (원광대학교 한의과대학 내과학교실) ;
  • 송봉근 (원광대학교 한의과대학 내과학교실)
  • Published : 1998.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

To know the effects of Gentiana macrophylla(GM) on the immune response, this study was undertaken. GM is one of the well-known oriental medicines for a lomg time used for the treatment of such diseases as arthralgia, headache, hepatitis, SLE, hemiparesis, and so on. To evaluate the effects of GM on immune response in the collagen induced arthritis, phagocytic activity of macrophages, proliferation of T-lymphocytes, secretion of nitric oxide in urine, and production of ROIs, $TNF-{\alpha}$ and nitric oxide in synoviocytes were measured. The results obtained in this study were as follows: 1. During the progress of CIA, the administration of GM enhanced phagocytic activity of macrophages in vivo and vitro. 2. During the progress of CIA, the administration of GM inhibited production of ROIs in synoviocytes. 3. During the progress of CIA, the administration of GM inhibited production of TNF- a in synoviocytes. 4. During the progress of CIA, the administration of GM inhibited proliferation of T lymphocytes. 5. During the progress of CIA, the administration of GM inhibited production of nitric oxide in synoviocytes. 6. During the progress of CIA, the administration of GM inhibited secretion of nitric oxide in urine. According to the above results, during the progress of CIA, it might be considered that GM has a curative effect on rheumatoid arthritis by controling immune response.

Keywords

References

  1. 本草學 康秉秀(外)
  2. 漢藥의 藥理$\cdot$成分$\cdot$臨床應用 陸昌洙(外)
  3. 中藥材學 聶慶喜
  4. 中華人民共和國藥典 中華人民共和國衛生部藥典委員會
  5. 神農本草經 v.2 吳普
  6. 新編中藥大事典(第2冊） 新文豊出版公司
  7. 漢藥臨床應用 李尙仁
  8. Chin. J. Physiol. v.11 no.1 本草中數種藥材對于大白鼠體溫之影響 Lousie G.Hutchins(外)
  9. 中藥 藥理與應用 王浴生
  10. 中藥硏究文獻摘要 劉壽山
  11. 臨床配合本草學 康秉秀(外)
  12. 植物學報 v.3 70種藥用植物抗菌效能的試驗 王嶽(外)
  13. Acta Physiol Sin v.22 Pharmacology of gentianine. I. Anti-inflammatory effect and action of pituitory-adrenal function of rat Sung C Y(外)
  14. 新醫藥學雜誌 中藥治療風濕病簡介 鄭複眞
  15. 中草藥通訊 秦艽注射液的制備及 臨床觀察板告 蘭洲東風制藥廳科技組
  16. 和漢藥物學 高木敬次郎
  17. The Pharmacology of Chinese Herbs KEE CHANG HYANG
  18. 醫藥淸報 v.19 no.3 류마티스관절염의 病態生理 김호연
  19. 대한내과학회지 v.27 no.3 류마티양 관절염에서 혈청 c－반응성단백에 관한 연구 박석건(外)
  20. 整形外科學 大韓整形外科學
  21. 면역학 서울대학교 의과대학
  22. 頭面 脊椎 四肢病의 診斷과 治療 羅昌洙
  23. 醫藥淸報 v.19 no.3 류마티스 관절염의 정의와 원인 박원
  24. 家庭醫學 醫學敎育硏修院
  25. 대한내과학회지 v.36 no.6 류마티스 관절염의 면역병인의 최근 경향 김호연
  26. Clinical lmmunol lmmunopathol. v.73 Collagen-induced Arthritis as a model of reumatoid arthritis Durie, FH.;Fava, RA.;Noelle, RJ.
  27. Methods Enzymol v.162 Collagen-induced Arthritis in the mouse Wooley, PH.
  28. Clin Exp Immunol v.89 Acceleration of onset of Collagen-induced Arthritis by intra－articular injection of tumor necrosis factor or transforming growth factor-beta Cooper， WO.;Fava, RA.;Gates, CA;Cremer, MA.;Towns, AS.
  29. J Immunol. v.141 In vivo administration with IL-laccelerates the development of Collage-induced Arthritis in mice Hom, JT.;Brendele, AM.;Carlson, DG.
  30. Arthritis Rheum v.32 Enhanced production of interleukin-6 in mice with type ll Collagen-induced Aithritis Takai, Y.;Seki, N.;Senoh, H.;Yokota, T.;Lee, F.;Hmaoka, T.;Fujiwara, H.
  31. 醫門寶鑑 周命新
  32. 東醫寶鑑 許浚
  33. 韓方物理療法學會誌 v.2 no.1 痺症의 分類와 洽療에 關한 考察 鄭錫熙(外)
  34. 東垣十種醫書 李東垣
  35. 景岳全書(上） 張介賓
  36. 實用中醫內科學 黃文東(外)
  37. 中醫內科學 上海中醫學院
  38. 痺證治驗 蔞多峰
  39. 大韓韓醫學會誌 v.11 no.1 痺證冶療의 用藥에 關한 小考 姜仁守
  40. 韓方物理療法科學會志 v.4 no.1 大羌活湯이 第II型 Collagen誘發 關節炎의 抗體에 미치는 影響 李昊根(外)
  41. 韓方物理療法科學會志 v.4 no.1 桂枝芍藥知母楊이 第ll型 Collagen誘發 關節炎의 抗體에 미치는 影響 申炳熙(外)
  42. 韓方物理療法科學會志 v.5 no.1 骨擔草가 第II型 Collagen誘發 關節炎의 抗體에 미치는 影響 嚴載元
  43. J lmmunol v.140 The human MHC-res-tricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8-T cells and is restricted to the DR region of the MHC complex Schmid, D. S.
  44. Int. Arch. Allergy Apple. Immunol. v.86 Natural cytotoxicity in adult acute leukemia Soerskaar, D.;Foerre, Oe.;Albrechtsen, D.;Slavem, P.
  45. Transplantation v.5 The failure if thymus-derived cells to produce antibody Davis, A.J.S.(et al)
  46. Eur. J．Immunol. v.11 F4/ 80, a monoclonal antibody directed specifically against the mouse macrophage Austyn, J.M.;Gordon, S.
  47. Anat. Rec. v.210 The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F40/ 80:macrophages associated with epithelia Hume, D.A.;Perry, V.H.;Gordon, S.
  48. J. Cell. Sci. v.66 The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F40/80:macrophages of bone and associated connective tissue Hume, D. A.;Loutit, J. F.;Gordon, S.
  49. J. Reticuloendothel Soc. v.32 Characterization of the mannose/fucose receptor on human mononuclear phagocytes Shepherd, V. L.;Comphell, E. J.;Sienior, R. M.;Stahl. P. D.
  50. J. Cell. Biol. Yeast mannose inhibits binding and phagocytosis of zymosan by mouse peritoneal macrophages Suny, S. S. J.;NeIson, R. S.;Silverstein, S. C.
  51. Cell. Immunol. v.79 Persistent expression of lgA－antigen on a Subpopulation of murine resident peritoneal macrophages WaIker. W. S.;Hester, R. B.;Beelen, R.H.J.
  52. J. Vet. Med. v.834 Measuring phagocytic capacity in polymorphonu clear cell of the pig a comparison between different assay Winter, M.;Buschmann, H. G.
  53. J. Antibiot. v.41 Deoxyspergualin therapy in autoimmune MRL/lpr mice suffering advanced lupus-like disease Nemoto, K.;T Mae;T. Takeuchi
  54. Reticuloendothel. Soc. v.23 Macrophage growth factor and it's relationship to colony stimulation factor Stewart, C. C.;Lin. H.
  55. G.L. antihypertensive component Kubo. M.;Archi, S.
  56. 대한내과학회지 v.36 no.6 류마토이드 활액막내 혈관내피와 말초단핵세포간의 유착에 관한 연구 변정원(外)
  57. 實用中西醫結合診斷治療學 陳貴廷
  58. 痺證治驗 蔞多峰
  59. 圖解鄕藥(生藥)大事典(植物篇） 鄭普燮(外)
  60. 中藥學 顔正華
  61. 全國中草藥匯編 全國中草藥匯編 編寫組
  62. 新編中藥炮制法 馬興民
  63. 內蒙古中草藥 內蒙古自怡區革命委員會 衛生局
  64. 本草綱目 李時珍
  65. 本草從新 吳儀洛
  66. 中藥大全 崔樹德
  67. 中藥무臨床應用 中山醫學院
  68. 增補本草備要 醫學硏究會
  69. 臨床實用中藥學 顔正華
  70. 實用中藥手冊 山東省人民醫院
  71. 現代實用中藥 葉橘泉
  72. Chinese Drug of PIant Origin W. Tang(外)
  73. 中華皮膚科雜誌 no.4 中藥水浸劑在試管內抗皮膚眞菌的觀察 曹仁烈(外)
  74. 中國醫學科學院 1956年 論文報告會論 文摘要 v.II 26種植物藥對于痲醉動物血壓的影響 李廳粹
  75. Jpn Kokai Tokyo Koho v.79 no.26 Antiinflammatory secoididoids Hayashi T(外)
  76. Planta Med v.60 no.5 Suppression of chemically and immunologically induced hepatic injuries by gentiopicroside in mice Kondo(外)
  77. Chung Hsi Chieh Ho Tsa Chih v.9 no.3 Observation on the treatment of systemic lupus erythematous with a Gentiana macropylla complex tablet and a minimal dose of prednisone Yuan ZZ(外)
  78. 카톨릭大學醫學部論文集 v.43 no.2 흰쥐에서 TyPe II Collagen으로 유발된 관절염의 임상양상 및 면역반응 박동준(外)
  79. 대한내과학회지 v.41 no.3 흰쥐의 제2형 Collagen유발 관절염:IgG항Collagen항체의 변화 박동준(外)
  80. Arthritis Rheum v.35 Interactions between anticollagen antibodies and chondrocytes[see comments] Takai T.;Jasin HE.
  81. Proc Natl Acad sci USA v.89 Williams, RO.;Feldmann, M.;Maini, RN.
  82. Arthritis Rheum v.31 Increased helper inducer and decreased Suppressor inducer phenotypes in the rheumatoid joint[see comments] Lasky HP;Bauer K;Pope RM
  83. J Rheumatolol v.19 Acute nonlymphocytic leukemia after treatment of system lupus erythematosus with immunosuppressive agents Lipsky PE
  84. The journal of Immunology v.156 lnhibition of $TNF-\alpha$ Expression by Adenosine Fereydoun G. Sajjadi(外)
  85. 新면역학 입문 中島泉
  86. 大韓韓醫學會誌 v.12 no.2 Rheumatoid Arthritis에서 東醫治療가 過酸化物의 活性度에 미치는 影響 羅昌洙
  87. Pharmacol Rev v.43 Nitric Oxide:Physiology, pathophysiolosy, and pharmacology Moncada. S.;Palmer, R.M.J.;Higgs, E.A. :
  88. Anne. Rev. Biochem. v.63 NITRIC OXIDE:A Physiologic Messenger Molecule D.S.Bredt(外)
  89. 대한 면역학회지 v.15 no.1 마우스 대식세포에 의해 생성되는 Nitric Oxide(NO)가 마우스 림프구의 증식에 미치는 영향 이복수(外)
  90. Arthritis Rheum v.36 Nitric oxide and arthritis Stefanovic-Racic M;Stadler J,;Evans CH
  91. Clin Orthop v.312 Nitric oxide and its role in orthopaedic disease Evans CH;Stefanovic-Racic M;Lancaster J
  92. Immunomethods v.47 Nitric oxide;what role does it play in inflammation and tissue destruction? Evans CH;Stefanovic-Racic M