The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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The Effects of Gamigunshimtang on the Ischemic Heart Disease & Heart cell in Rats

허혈성심장(虛血性心臟) 및 심장세포(心臟細胞)에 대(對)한 가미건심탕(加味健心湯)의 실험적(實驗的) 연구(硏究)

  • Park, Jung-Mi (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Moon, Sang-Kwan (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Go, Chang-Nam (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Gi-Ho (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Kyung-Suk (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Bae, Hyung-Sup (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Kyung-Sup (Department of Circulatory Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 박정미 (경희대학교 한의과대학 심계내과학교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학교실) ;
  • 고창남 (경희대학교 한의과대학 심계내과학교실) ;
  • 조기호 (경희대학교 한의과대학 심계내과학교실) ;
  • 김영석 (경희대학교 한의과대학 심계내과학교실) ;
  • 배형섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 이경섭 (경희대학교 한의과대학 심계내과학교실)
  • Published : 1998.04.30
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Abstract

The effects of Gamigunshimtang on the isolated perfused ischemic heart in rats, heart rates, left ventricular pressure, cardiac blood flow and cardiotoxicity were stu.died in H9C2 myoblast cell, myocardial slice culture The results were as follows: 1. The administration of Gamigunshimtang to the rat recovered effectively heart rate, left ventricular pressure and flow rate from the experimental ischemia in perfused rat heart. The release of lactic dehydrogenase after the ischemia also decreased compared to the control group. 2. The administration of Gamigunshimtang to H9C2 myoblast culture enhanced the cell proliferation and protected against doxorubicin and allylamine induced release of the lactic dehydrogenase into the culture medium. It also protected effectively against doxorubicin and allylamine induced decrease of Ca ATPase activity and the increase of NADPH-cytochrome C reductase activity in the microsome. 3. The administration of Gamigunshimtang to the rat myocardial slice culture protected effectively against doxorubicin and allylamine induced decreases of protein synthesis and ATP content, and increases of cvtosolic enzyme, creatin kinase into the medium and lipid peroxidation.

Keywords

References

  1. 原色 天然藥物大事典(2版） 金在佶
  2. 東洋醫學 診療要鑑 金定濟
  3. 方證新編 宋炳基
  4. 東醫臨床方劑學 尹吉榮
  5. 本草學 李尙仁
  6. 東醫寶鑑 許浚
  7. 本草學 全國韓醫科大學 本草學敎授
  8. 순환기 학회지 v.22 no.1 적출가토 활동 심장에서 Allopurinol의 심근보호에 관한 연구 김성구
  9. 瓜蔞薤白半夏湯 및 加味瓜蔞薤白半夏湯이 虛血性心疾患에 미치는 影響 金仁燮
  10. 大韓胸部外科學會誌 v.13 no.3 冷血 potassiunm 心停止液을 이용한 心筋保護의 實驗的 硏究 이동준
  11. 麝香蘇合元이 再灌流裝置下의 흰쥐 심장에 미치는 영향 李英彬
  12. 圓光韓醫學 v.3 no.1 溫膽湯 煎湯液이 心臟機能에 미치는 影響 任埈模;文炳淳;金世吉
  13. 虛血性 心臟에 대한 勝金散의 實驗的 硏究 全燦鎔
  14. 仁齊直指方 楊仁齊
  15. 心臟的臨床檢査 陳秉良
  16. Biomesstechnik-Verlag March Gmbh, D-7806 March The isolated perfused warm-blooded heart according to Langendorff H. Dehnert;H. J. Doring
  17. The principles and practice of medicine Harvey A. Mc Gehee
  18. Cardiology Plowman, P. N.
  19. J.Mol. Biol. Cellular v.14 Biotransformation of cardiovascular toxin, allylamine, by rat and human cardiovascular tissue Boor, P. J.;Nelson, T. J,
  20. J. Natl. Cancer Inst. v.155 Adriamycin-a review Carter, S. K.
  21. Toxicol．Appl. Pharmacol. v.107 Mitochondrial regulation of superoxide by $Ca^{2+}$:an alternative mechanism for the cardiotoxicity of doxorubicin Chacon, E.;Acosta D.
  22. Toxicol. Appl. Pharmacol. v.124 Cardiotoxicity of heterocyclic amine food mutagens in cultured myocytes and in rats Davis, C. D.;Farb, A.;Thorgeirsson, S. S.;Virmani, R,;Synderwine, E. G.
  23. Biochem. Pharmacol. v.34 The protective effects of taurine on hypoxia(performed in the absence of glucose) and on reoxygenation(in the presence of glucose) in Guinea－pig heart Fraconi, F.;Isabella, S.;Paola, F.;rosanna, M.;Baccaro, C.;Montorsi, L.;Bandinelli, R.;GioHi, A.
  24. In Methods in Enzymology Free radicals and metal ions in human dicease Halliwell, B.;Gutteridge, J. M, C;L Packer;A. N. GIazer(eds.)
  25. Ann. Thorac. Surg. v.47 Modified Reperfusate After Long-Term Preservation of the Heart Jeffrey C. Milliken;Anne M. Billingsley;Hillell Laks.
  26. Anne. Thorac. surg. v.32 no.1 The optimal Potassum Concentration in Cardioplegic Solutions John H. Rousou;Richard M. Engelman;William A. Dobbs;Stanley Lemeshow
  27. Toxicol v.71 The effect of hexane on the ventricular fibrillation threshold of the perfused rat heart Khedun, S. M.;Maharaj, B.;Leary, W. P.;Lockett, C. J.
  28. Anal. Biochem. v.175 Clinical and biochemical applications of luciferases and luciferins Kricka, L. J.
  29. Pfugers Arch. Ges. Physiol. v.61 Langendorff, O. Untersuchungen;Uberleberden Sagertierzen
  30. Cardiovasc. Res. v.24 Antiarrhythmic effect of amiodarone on doxorubicin acute toxicity working rat hearts Lambert, C.;Mossiat, C.;Tanniere. Z. M.;Maupoil, V.;Rochette, L.
  31. Biomed. Biochem. Acta． v.45 The cultured myocardial cells as a model in cardiac research Morwinski, R.
  32. Bichem Biophys. Res. Commun. v.204 Human cardiac fibroblasts express an angiotensin receptor with unusual binding characteristics which is coupled to cellular proliferation Neub, Regitz-Zagrosek, V.;Hildebrandt, A.;Fleck, E.
  33. FASEB Journal v.4 Doxorubicin cardiotoxicity:Analysis of prevailing hypothesis OIson, R. D.;Mushlin, P. S.
  34. Toxicol. Methods. v.2 Organ culture of rat myocardial slices:An alternative in 269 vitro tool in organ specific toxicology Parrish, A. R.;Shipp, N. G.;Spall, R. D.;Dorr, R. T.;Korumdieck, C. L.;Gandolfi, A. J.;Brendel, K
  35. Toxico. Appl. Pharmacol. v.102 Maitotoxin-induced myocaidial cell injury:Calcium accumulation followed by ATP depletion precedes cell death Santostasi, G.;Kutty, R. K.;Bartirelli, A. L.;Yasumoto, T.;Krishna, G.
  36. Cancer Res. v.53 Characterization of experimental mitoxantrone cardiotoxicity and its partial inhibition by ICRF-187 in cultured neonatal rat heart cells Shipp, N. G.;Dorr, R. T;Alberts, D. S.;Dawson, B. V.;Hendrix, M.
  37. Circulation v.66 Possible role for cytotoxic oxygen metabolites in the pathogenesis of cardiac ischemic injury Shlafer M;Kane PF(et al)
  38. Toxicol. Appl. Pharmacol. v.107 Allylamine and acrolein toxicity in perfused rat hearts Sklar, J. L.;Anderson, P. G.;Boor, P. J.
  39. Life Sci. v.36 Maintenance of adult rat liver slices in dynamic organ culture Smitsh, P. F.;Gandolfi, A. J.;Krumdieck, C. L.;Putnam, C. W.;Zukowski, C. F. lll; Davis, W. D.;Brendel, K.
  40. Prog Cardiovasc dis. v.28 The oxygen free radical system:A fundamental mechanism in the production of myocardiac necrosis Thompson JA;Hess ML
  41. Cancer Res. v.50 di-N, N'-Dicarboxamidomethyl-N, N'-dicarboxy-methyl-1, 2-diaminopropane (ICRF-198) and d-1, 2-Bis (3, 5-dioxopiperzine-1-yl) propane (ICRF-187) inhibition of Fe3+ reduction, lipid peroxidation, and CaATPase inactivion in heart microsomes exposed to Adriamycin Vile, G. F.;Winterboum, C. C.