도홍음(桃紅飮)이 Collagen 등(等)으로 유발(誘發)한 혈전(血栓) 및 혈액점도(血液粘度)에 미치는 영향(影響)에 관(關)한 연구(硏究)

  • 발행 : 1998.11.30

초록

This study was performed to prove the antithrombotic effects of DoHongYeum fluid by way of experimental methods. The thrombosis was induced by injection of collagen the mixture (0.1ml/10g, 2mg/kg B.W)plus serotonin (5mg/kg B.W) into the caudal vein of rat, 2 hours after liquid extract of DoHongYeum was oral administration. The effect of the fluid of DoHongYeum was rxamined by the number of RBC and platelets, bleeding time, blood clotting time, death rate, platelet aggregation, plasmacoagulation factor activity, exvivo and fibrinolytic activity of englobulin fracture in the rats. The results were summerized as followings. 1. The number of RBC and platelets was significantly increased in DoHomeYeum group incomparison with the control group. 2. Bleeding time was significantly shortened in DHY group in comparison with the controlgroup. 3. Blood clotting time was significantly prolonged in DHY group in comparison with the control group. 4. The death rate of mouse was inhibited in DHY group in comparison with the control group. 5. The platelet aggregation was inhibited in DHY group in comparison with the control group. 6. The prothrombin time and activated partial thromboplastin time on the test of plasmacoagulation factor activity was prolonged but was not valuable in DHY group. 7. Fibrinogen lyses time of rat was reduced and lyses area was increased in DHY group incomparison with the control group. 8. Fibrinogen lyses time of rat in vitro assay was reduced in DHY group. From the above results, it was thought that the DoHongYeum could be applied effectively in the thrombosis.

키워드

참고문헌

  1. 病理學 金春元
  2. 病理學 慨論 孫泰重
  3. 仲景全書 張機
  4. 精校黃帝內經 洪元植
  5. 諸病源侯論 巢元方
  6. 臨證指南醫安 葉桂
  7. 中西匯通醫書五種 唐容川
  8. 六科準繩 王背堂
  9. 血證論 唐宗海
  10. 實用中西醫診斷治療學 連貴廷
  11. 臟腑辨證論治 金完熙(外)
  12. 東醫生理學 大韓東醫生理學會
  13. 活血化瘀臨床實踐 顔德馨
  14. 血瘀症的診斷和治療 兪芝江
  15. 中醫內科學 山東中醫學院內科學敎室
  16. 中醫症候鎰別診斷學 中國中醫硏究院
  17. 漢藥臨床應用 李尙仁(外)
  18. 活血化瘀硏究 姜春華
  19. 簡明方劑辭典 江克明(外)
  20. 類證治裁 林佩琴
  21. 醫林改錯 王淸任
  22. 仲景全書 張仲景
  23. 東垣十種醫書 李東垣
  24. 漢方醫學用語辭典 蔡仁植(外)
  25. 病症診治 申天浩
  26. 東洋醫學大辭典 謝觀
  27. 釘河問三六書 劉完素
  28. 備急千金要方 孫思邈
  29. 丹溪心法 朱震亨
  30. 醫種必讀 李中梓
  31. 景岳全書(上) 張介賓
  32. 漢醫學辭典 金賢濟;洪元植(編著)
  33. 中醫學基礎 上海中醫學院
  34. 韓方病理學 鄭遇悅
  35. 中醫學 江蘇新醫學院(編)
  36. 中醫學問答(上) 楊醫亞
  37. 新編中醫學槪要 廣東中醫學院(等編)
  38. 中醫病因病機學 宋鷺永
  39. 風火痰瘀論 章眞如
  40. 病理學(上) 中山醫學院
  41. 漢藥處方의 構成과 解說 河硬錫
  42. 東醫學의 方法論硏究 尹吉榮
  43. 大韓韓醫學會誌 v.5 no.1 韓醫學에서의 瘀血에 대한 槪念 康舜洙
  44. 東醫病理學會誌 v.4 瘀血의 槪念에 대한 東醫學 的考察 田炳勳;禹元洪;鄭遇悅
  45. 圓光大學校論文集 瘀血에 關한 文獻的 考察 金暎益
  46. 方劑學會誌 v.2 no.1 活血祛瘀劑에 關한 文獻的 考察 康舜洙;姜惠永
  47. 東洋醫學 v.2 no.4 韓醫學의 客觀化와 東西醫學病名統一을 위한 方法 尹吉榮
  48. 新中醫 v.8 活血化瘀辨治常見心臟病 劉亦造
  49. 漢藥臨床應用 李尙仁(外)
  50. 原色本草維新 辛民敎
  51. 中藥學 高學敏
  52. 褘藥學 11 陸昌洙(外)
  53. 本草綱目 李時珍
  54. 本草學 李尙仁
  55. 中草藥學 上海中醫學院
  56. 增補 木草備要 白允基
  57. 鄕藥粲成方 李泰浩
  58. 本草三家合註 陳修園(外)
  59. 漢藥의 藥理,成分.臨床應用 金成萬(外)
  60. 申氏本草學 申佶求
  61. 韓國本草學 陸昌洙(外)
  62. 溢壽本草 丁海哲
  63. 本草三家合註 陳修園(外)
  64. 湯液本草 王好古
  65. 東醫病理學會誌 桃紅四物湯이 Endotoxin으로 誘發 된 血栓症에 미치는 影響 郭瑾信
  66. 血府逐瘀湯이 血栓症과 皮下血腫 에 이치는 影響 崔昇勳
  67. 東醫病理學會誌 v.8 黃民桃紅湯이 Endotoxin으로 誘發 된 白鼠의 血栓症에 미치는 影響 李鎭弘
  68. 慶熙韓醫大論文集 疏經活血湯이 血栓症에 미치는 影響 兪企英
  69. 東醫病理學會誌 復元活血湯이 Endotoxin으로 誘發 된 血栓症에 미치는 影響 朴文秀
  70. 東醫病理學會誌 v.13 血栓症 및 高糖度血症에 關한 補陽還五湯의 實驗的 硏究 金珖德(外)
  71. 東醫病理學會誌 v.8 補陽還五湯과 加味補陽還五湯이 Endotoxin으로 誘發된 白鼠의 血栓症에 미치는 影響 全英秀
  72. J. Phamacol. v.225 Mouse antithrombotic assay : A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by alcohol. Dimino, G.;Silver M. J.
  73. Pharmacology and Toxicology, v.70 Antithrombotic activity of a new pyrazosine derivative determined by the mouse antithrom-botic assay Petrusewiez, J.(et al)
  74. Throm. Res. v.54 Role of free radicals in pulmonary thromboembolism in mice Dikshit, M.(et at)
  75. Life Science v.51 A novel insight into the mechanism of the antithrombotic action of defibrotide Rosella T.(et at)
  76. Thrombosis and Hemostasis v.66 no.4 Antithrombotic effect of MCI-9042, a new antiplatelet agent on experimental thrombosis models H. Hara(et al)
  77. Tromb. Res. v.52 Comparison of hirudin and hirudin PAC-terminal fragments and related analogs as antithrombin agents Krstenansky J. L.;Mao, S. J. T.
  78. Prostaglandins v.32 Effect of prostsglandins and arachidonic acid on baboon cerebral and mesenteric arteries Hayashi, S.;Park, M. K.
  79. Eur. J. Pharmacol. v.81 Comparison of the potencies of some prostaglandins as vasodilators in three vascular beds of the anaesthetised dog Lumley, P.(et al)
  80. Thrombosis and Hemostasis Antithrombotc activity of a novel C-terminal hirudin analog in experimental animals R. J. Broersma(et al)
  81. J. phsiol v.168 the aggregation of blood platelets Born, G. C. R.;Cross, M. J.
  82. Thrombosis Res. v.65 TFC-612, a prostaglandin El derivative, enhance fibroyticy activity in rats Yukio Motoyama(et al)
  83. Tromeb. Hemostasis v.47 Effect of prostacyclin on fibrolytic activity inpatients with arteriosclerosis obliterans Kiek, A.d.;Yrabka, E.k.(et al)
  84. Tromb. Haemostasis v.46 Th effect of prostacyclin infusion on tissue plasminogen activator Winther, K.(et al)
  85. Angiology v.35 The role of fibrinolysis in the therapy of peripheral vascular disease Ambrus, C. N.(et al)