Applied Biological Chemistry
- Volume 41 Issue 8
- /
- Pages.613-615
- /
- 1998
- /
- 2468-0834(pISSN)
- /
- 2468-0842(eISSN)
Existence of Thermally Stable Thrombin Inhibitors in Soybean Paste, Doenjang
- Kim, Dong-Chung (Department of Agricultural Chemistry, College of Agricultural and Life Sciences, Seoul National University,Korea Nutrition Research Institute, Korea University) ;
- In, Man-Jin (Korea Nutrition Research Institute, Korea University) ;
- Oh, Nam-Soon (Department of Food Science and Technology, Kongju National University) ;
- Hwang, Woo-Ik (Korea Nutrition Research Institute, Korea University) ;
- Jung, Jin (Department of Agricultural Chemistry, College of Agricultural and Life Sciences, Seoul National University)
- Published : 1998.12.31
Abstract
Antithrombotic function of doenjang was investigated using thoroughly desalted aqueous extract. In the presence of the extract, thrombin suffered loss of its fibrin-clotting activity, whose extent increased in a dose-dependent manner. The active substance involved in thrombin inhibition showed a high thermal stability. Results of Sephadex G-25 permeation chromatography indicated that there were at least two soluble thrombin inhibitors in doenjang with different molecular sizes.