Journal of Pharmaceutical Investigation
- 제28권4호
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- Pages.215-221
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- 1998
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
클로르프로마진의 클로르프로마진 설폭시드로의 대사동태
Metabolite Kinetics of Chlorpromazine to Chlorpromazine Sulfoxide in Rats
- Jeong, Sug-Jin (College of Pharmacy and Research institute of Drug Development, Chonnam National University) ;
- Na, Han-Kwang (Department of Clinical Pharmacology, Toxicology Research Institute) ;
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Lee, Yong-Bok
(College of Pharmacy and Research institute of Drug Development, Chonnam National University)
- 발행 : 1998.12.20
초록
In order to elucidate the fraction of sulfoxidation in the over all in vivo metabolism of chlorpromazine (CPZ), the sulfoxidation of CPZ to chlorpromazine sulfoxide (CPZSO) was studied in rats. CPZ (10 mg/kg) and CPZSO (1 mg/kg) were injected into the rat femoral vein, respectively. And the pharmacokinetic parameters were obtained from the plasma concentration-time profiles of CPZ and CPZSO determined by the simultaneous analysis using high-performance liquid chromatography. It was supposed that these drugs were almost metabolized in vivo because the total excreted amounts of CPZ and CPZSO via urinary and biliary route were lower than 1.4% and 10.61% of the administered dose, respectively. And also, it was found that the fraction of systemic clearance of CPZ which formed CPZSO